Myeloproliferative Neoplasms in Children and Adolescents and Thrombosis at Unusual Sites: The Role of Driver Mutations.

Myeloproliferative neoplasms (MPNs) in childhood and adolescence are rare and seldom complicated by thrombosis. We describe 3 cases of thrombosis at unusual sites in young patients with MPNs. In the pediatric MPN population, unlike in adult MPNs, a clonal mutation is identifiable in only a minority of cases (22% to 26%).

A no-prophylaxis platelet-transfusion strategy for hematologic cancers.

Background: The effectiveness of platelet transfusions to prevent bleeding in patients with hematologic cancers remains unclear. This trial assessed whether a policy of not giving prophylactic platelet transfusions was as effective and safe as a policy of providing prophylaxis.

Methods: We conducted this randomized, open-label, noninferiority trial at 14 centers in the United Kingdom and Australia.

Ten-year pattern of red blood cell use in the North of England.

Background: An understanding of current and changing patterns of red blood cell (RBC) use will help predict future demands and aid future planning for transfusion services. It can also highlight areas where efforts to optimize RBC use are most likely to be productive.

Study Design And Methods: Surveys were conducted in two 14-day periods of all RBC transfusions in a geographic region of England supplied by a single blood center.

Early diagnosis and treatment of cobalamin deficiency of infancy owing to occult maternal pernicious anemia.

We report case of an infant who presented with failure to thrive and developmental delay at 4 months of age. He was diagnosed to have vitamin B12 deficiency and antibodies to intrinsic factor secondary to undiagnosed maternal pernicious anemia. The child was treated with hydroxocobalamin and now at 2 years of age, he is developing and growing within normal range.