Donor Site Outcomes Following Autologous Breast Reconstruction with DIEP Flap: A Retrospective and Prospective Study in a Single Institution.

The deep inferior epigastric perforator artery (DIEP) free flap is the most commonly performed autologous breast reconstruction. Despite the relative reduction in donor site complications compared to nonmuscle-sparing options, there is still high morbidity associated with this surgery. The purpose of this study is to compare outcomes and complications at our institution and to discuss potential quality improvement initiatives.

Exploring the impact of HIV infection and antiretroviral therapy on placenta morphology.

Introduction: Women living with HIV experience more adverse birth outcomes; the mechanisms are not fully understood. We examined placenta morphology and associations with birth outcomes in a Canadian cohort of women living with HIV (HIV) on antiretroviral therapy (ART) from conception and HIV-uninfected (HIV) women.

Methods: Term placentas from 94 women (40 HIV, 54 HIV) were studied.

COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine.

Objectives/background And Objectives: Prior epidemics of high-mortality human coronaviruses, such as the acute respiratory syndrome coronavirus (SARS-CoV or SARS-1) in 2003, have driven the characterization of compounds that could be possibly active against the currently emerging novel coronavirus SARS-CoV-2 (COVID-19). Presently, no approved treatment or prophylaxis is available for COVID-19. We comment on the existing COVID-19 research methodologies in general and the published reporting.

Interferon beta-1a for patients with moderate to severe acute respiratory distress syndrome: a systematic review and meta-analysis of randomized trials.

Introduction: Acute respiratory distress syndrome (ARDS) is a life-threatening disease characterized by respiratory failure with rapidly progressing inflammation. Currently, no effective pharmacological treatment for ARDS is available.

Objectives: We conducted this systematic review and meta‑ analysis to examine the use of interferon beta-1a in patients with ARDS.

Clinical evaluation of sealants and preventive resin restorations in a group of environmentally homogeneous children.

Purpose: Pit and fissure sealants reduce occlusal caries when proper patient selection and application techniques are followed. To increase retention rate of sealants over time, good adaptation and deep sealant penetration are important. Studies remain inconclusive, however, as to determining if the bur preparation of pits and fissures would increase the adaptation and penetration thus improving sealant retention.