Publications by authors named "Diankun She"
Circular RNAs (circRNAs) are a class of non-coding RNAs which take part in the regulation of the initiation and development of different types of cancer. Numerous studies have demonstrated that circRNAs are involved in the progression of osteosarcoma (OS) as well. Thus, we put our emphasis on the exploration of crucial circRNAs in the process of OS initiation and progression.
View Article and Find Full Text PDFThe prognosis of lung metastatic osteosarcoma (OS) remains disappointing. siRNA-based gene silencing of VEGFR2 is a promising treatment strategy for lung metastatic OS, but there is a lack of safe and efficient delivery systems to encapsulate siRNAs for in vivo administration. This study presented a synthetic biological strategy that remolds the host liver with synthesized genetic circuits for efficient in vivo VEGFR2 siRNA delivery.
View Article and Find Full Text PDFArticle Synopsis
- Osteosarcoma (OS), the most common malignant bone tumor in young people, has a key gene called PLOD2 that enhances collagen cross-linking and influences cancer progression, but its relationship with OS is not fully understood.
- Recent studies showed that PLOD2 is highly expressed in OS, correlating with poorer patient outcomes and promoting cell migration, invasion, and the formation of new blood vessels (angiogenesis), thus worsening metastasis.
- PLOD2 also impacts immune cell behavior in OS, indicating its potential as a therapeutic target for improving treatment strategies, especially in the context of clinical immunotherapy.*