Emerging roles of intratumoral microbiota: a key to novel cancer therapies.

Microorganisms, including bacteria, viruses, and fungi, have been found to play critical roles in tumor microenvironments. Due to their low biomass and other obstacles, the presence of intratumor microbes has been challenging to definitively establish. However, advances in biotechnology have enabled researchers to reveal the association between intratumor microbiota and cancer.

Synthesis of α-Chloroboronic Esters via Photoredox-Catalyzed Chloro-Alkoxycarbonylation of Vinyl Boronic Esters.

α-Chloroboronic esters are a class of stable multifunctional molecules that show unique applications in pharmaceutical science and organic chemistry. Despite their apparent utility, the synthetic methods of these compounds remain limited. Herein, a novel strategy for the efficient synthesis of α-chloroboronic esters is developed via photoredox-catalyzed chloro-alkoxycarbonylation of vinyl boronic esters.

IL-1β stimulates ADAMTS9 expression and contributes to preterm prelabor rupture of membranes.

Background: Preterm prelabor rupture of membranes (pPROM) is a leading cause of neonatal morbidity and mortality. While intra-amniotic infection is a well-established driver of pPROM, the role of sterile intra-amniotic inflammation remains unclear. Recent evidence suggests that interleukin-1 beta (IL-1β) promotes extracellular matrix (ECM) remodeling via downstream effectors, a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9), while protein O-fucosyltransferase 2 (POFUT2) facilitates its O-fucosylation and secretion, amplifying ECM degradation.

A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma.

The level of thyroidectomy-related regret in patients with clinically low-risk papillary thyroid microcarcinoma (PTMC) and the determinants of decision regret are largely unknown. Here, we show that 319 (24.2%) of those who undergo thyroidectomy and 4 (3.

Central sterile supply departament management on hospital-associated infections: a systematic review and meta-analysis.

Hospital-associated infections (HAIs) pose significant risks in clinical settings, and sterile supply centers management plays a crucial role in infection control. This systematic review and meta-analysis aimed to evaluate the impact of supply center management on the incidence of HAIs and adverse events. The systematic review encompassed studies that compared supply center management protocols with standard care.

A retrospective study of neoadjuvant novel hormonal therapy prior to radical prostatectomy for high-risk prostate cancer.

Purpose: This study aims to retrospectively describe the perioperative outcomes and short-term oncological outcomes of high-risk prostate cancer patients treated with neoadjuvant novel hormonal therapy (NNHT) combined with radical prostatectomy (RP) or RP alone.

Materials And Methods: Fifty-five male patients underwent RP and were categorized based on whether NNHT was administered preoperatively. Clinical baseline characteristics, perioperative outcomes, and biochemical recurrence (BCR) rate were summarized using mean, standard deviation, medians, interquartile ranges, and frequencies.

Bipyridine covalent organic framework aerogel for highly selective recovery of palladium in wastewater.

Palladium (Pd), a rare and precious metal, is highly valued due to its non-renewable nature and significant cost. Therefore, recovering palladium from industrial wastewater is of great importance but remains a challenge. Herein, a composite aerogel adsorbent has been developed by linking a bipyridine covalent organic framework, termed TpBpy, with chitosan (CS) through robust covalent bonds.

Qingre Huayu Jianpi prescription alleviates the inflammatory transformation of colitis-associated colorectal cancer by inhibiting the IL-17RA/ACT1/NF-κB axis.

Ethnopharmacological Relevance: Inflammation-to-cancer transformation is critical for the progression of ulcerative colitis to colitis-associated colorectal cancer (CAC).

Aim Of The Study: To explore the role and potential mechanisms of Qingre Huayu Jianpi prescription (QHJ) treatment in the development of CAC.

Materials And Methods: Combined network pharmacology and transcriptome analyses were used to investigate QHJ-associated targets and pathways in the context of CAC.

Investigation of cell development and tissue structure network based on natural Language processing of scRNA-seq data.

Background: Single-cell multi-omics technologies, particularly single-cell RNA sequencing (scRNA-seq), have revolutionized our understanding of cellular heterogeneity and development by providing insights into gene expression at the single-cell level. Investigating the influence of genes on cellular behavior is crucial for elucidating cell fate determination and differentiation, cell development processes, and disease mechanisms.

Methods: Inspired by NLP, we present a novel scRNA-seq analysis method that treats genes as analogous to words.

Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complex.

The telomerase complex consists of a protein component (TERT), which has reverse transcriptase activity, and an RNA component (TERC), which serves as a template for telomere synthesis. Evidence is rapidly accumulating regarding the non-canonical functions of these components in both normal or diseased cells. An oligonucleotide-based drug, the first telomerase inhibitor, secured FDA approval in June 2024.

Postoperative Sclerotic Modic Changes after TLIF:whether it is different between n-HA/PA66 and PEEK cage?

Objectives: This study aimed to compare short-term outcomes between nano-hydroxyapatite/polyamide 66 (n-HA/PA66) cage and polyetheretherketone (PEEK) cage in sclerotic Modic changes (MCs) following transforaminal lumbar interbody fusion (TLIF) and explore the effects of these cages on postoperative sclerotic MCs.

Methods: We retrospectively screened 1076 patients from September 2012 to September 2024 identifying 134 patients (154 levels) with sclerotic MCs after TLIF. Patients were divided into n-HA/PA66 group and PEEK group.

A lignin-based multifunctional elastomer via facile fabrication for wearable strain sensors.

Elastomer-based electronics have the potential to maintain both electrochemical conductivity and mechanical properties simultaneously, paving the way for the development of stretchable sensors. However, creating sensors that are extremely stretchable, wearable, and highly sensitive remains a significant challenge. In this work, we present a novel fully bio-based multifunctional polymer (FPL/PTA) designed using thioctic acid (TA) and formaldehyde-protected lignin (FPL).

Single-pixel diffractive imaging via regularized complex-amplitude retrieval.

For high-fidelity single-pixel complex-amplitude measurement, we implement robust and regularized wavefront separation by integrating multi-distance correlated reconstruction with constrained alternating projection retrievals. An adaptive dynamic weighting mechanism for group-wise wavefront updates further reinforces the stability and accuracy of imaging convergence. Additionally, a compressed phase retrieval driven by sparsity priors markedly optimizes efficiency by enabling wavefront reconstruction with single-frame diffraction.

α‑1 Antitrypsin is a potential target of inflammation and immunomodulation (Review).

α‑1 Antitrypsin (AAT) is an acute phase protein encoded by the gene. This multifunctional protein serves several roles, including anti‑inflammatory, antibacterial, antiapoptotic and immune regulatory functions. The primary role of AAT is to protect tissues and organs from protease‑induced damage due to its function as a serine protease inhibitor.

Optimizing charge pathways by interface engineering in FeO/CoO/Co(PO) heterostructures for superior oxygen evolution reaction.

The Oxygen Evolution Reaction (OER) is vital for energy conversion and storage. This study presents a multi-heterostructure catalyst, FeO/CoO/Co(PO), created by encapsulating Fe ions in COF/MOF pores through grinding and one-step pyrolysis. The catalyst demonstrates exceptional OER performance, achieving an ultra-low overpotential of 232 mV, outperforming the CoO/Co(PO) single heterostructure.

Estimating water scarcity risks under climate change: A provincial perspective in China.

Water is a crucial raw material in economic production activities. Research indicates that water scarcity can lead to significant economic output losses (water scarcity risk, WSR), affecting not only the local area (referred to as local water scarcity risk, LWSR) but also causing economic losses to other regions through trade networks (referred to as virtual water scarcity risk, VWSR). With climate change exacerbating this challenge, understanding the water scarcity risk under changing climatic conditions is essential.

The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia.

Background: Dual induction with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has made acute promyelocytic leukemia (APL) a curable disease. However, differentiation syndrome (DS) can be a life-threatening complication of induction therapy. It is considered to result from a severe systemic inflammatory response mediated by increased expression of cytokines, chemokines, and adhesion molecules on differentiating blast cells.

Study of Construction of Innovative Barite/Waterborne Polyurethane/Low-Density Polyethylene Composites for Enhanced X-Ray Shielding Performance.

X-rays' high-energy nature poses risks to human health. Traditional X-ray shielding materials often contain toxic lead and have drawbacks like bulkiness and rigidity. Consequently, there is an increasing need to develop lightweight, non-toxic, flexible, and efficient shielding materials.

[Classification of Alzheimer's disease based on multi-example learning and multi-scale feature fusion].

Alzheimer's disease (AD) classification models usually segment the entire brain image into voxel blocks and assign them labels consistent with the entire image, but not every voxel block is closely related to the disease. To this end, an AD auxiliary diagnosis framework based on weakly supervised multi-instance learning (MIL) and multi-scale feature fusion is proposed, and the framework is designed from three aspects: within the voxel block, between voxel blocks, and high-confidence voxel blocks. First, a three-dimensional convolutional neural network was used to extract deep features within the voxel block; then the spatial correlation information between voxel blocks was captured through position encoding and attention mechanism; finally, high-confidence voxel blocks were selected and combined with multi-scale information fusion strategy to integrate key features for classification decision.

Unveiling the Genomic Features and Biocontrol Potential of Against Root Rot Pathogens.

species are among the most significant pathogens causing root rot in . In this study, a strain of was isolated from the rhizosphere soil of and subjected to whole-genome sequencing. Plate confrontation experiments were conducted to investigate the antagonistic effects of against , , and , the primary species causing root rot.

Comparison study of two anastomosis techniques in right hemicolectomy: a systematic review and pooling up analysis.

Purpose: This study aims to compare side-to-side anastomosis (SSA) and end-to-side anastomosis (ESA) in laparoscopic right hemicolectomy from multiple perspectives to guide the selection of the optimal anastomotic technique.

Methods: This review was pre-registered with PROSPERO (CRD42024614418). A comprehensive literature search was performed using Embase, PubMed, Cochrane Library, and China Biology Medicine (CBM).

Immunogenicity and safety of 1 versus 2 doses of quadrivalent-inactivated influenza vaccine in children aged 3-8 years with or without previous influenza vaccination histories.

This study assessed the immunogenicity and safety of a quadrivalent influenza split-virion vaccine (IIV4) in children with and without prior influenza vaccination. An open-label, phase IV clinical trial was conducted in healthy children aged 3-8 years in Pizhou, Jiangsu Province, China. Children with ≥2 doses of prior influenza vaccination (Influenza Vaccination Group) and those with no prior vaccination (Influenza Vaccine-naïve Group) were given two doses of IIV4, 4 weeks apart.

 (Primulaceae), a new species in  sect.  from Sichuan, China.

T.Shuai, Lei Cai & Z.K.