A clinicomorphological study of pituitary tumors associated with the clinical syndrome of acromegaly.

Transsphenoidal adenomectomy was done on 125 acromegalics. A clinicomorphological study was performed on 113 of these patients. The distribution of morphological types of tumors was similar in both sexes.

[Treatment of patients with postmenopausal osteoporosis and steroid-induced osteoporosis with the preparation Rocaltrol (1,25/OH/2 vitamin D3)].

A clinical trial of the drug "Rocaltrol" was carried out on 16 patients with osteoporosis, II of them with menopause osteoporosis and 5 with steroid-induced osteoporosis. The mean age of the patients was 53.1 +/- 11.

[The value of computerized tomography for the diagnosis of diabetic osteoarthropathy].

The diagnostic possibilities of computed tomography as compared to conventional radiology are presented. Morphological changes, which can be identified by normal x-rays, can be shown by computed tomography without any disturbing overshadowing. The computed tomography is showing especially well necrotic lesions, pathological fractures, and joint changes.

[Determination of changes in the mineral content of the bones of diabetics by photon absorption measurements].

The absolute value of mineral content of the bones (MCB), obtained from a single measurement and compared with the so called mean or normal value for a certain age-sex population, cannot be a reliable diagnostic index owing to the great individual discrepancies of MCB, reaching even to +/- 40%. Only the successive, dynamic and compared within each other values of MCB could be of use for the purposes of medical diagnostics and therapy. As a result for periodic measurements in patients with diabetes, the juvenile diabetes was concluded to be characterized by a higher initial MCB value and a faster demineralization, contrary to diabetes that advanced at an older age.

[Ischemic bone necrosis in Itsenko-Cushing disease].

X-ray alterations of the type ischemic osseous necrosis were established in three patients (two females and one male) with Icenko-Cushing disease. In the first case--the haed of femur was unilaterally affected: in the second--bilateral lesions with the same localization; and in the third--a combination of changes in the head of femur and the heads of some metatarsal bones. In all patients, secondary ostheoarthrosis alterations were also observed.

[Clinical and functional study on the evolution of diabetic macroangiopathy].

Forty seven patients and 26 healthy subjects controls were followed up in the course of 8 years. Twenty fine from the diabetic patients were without vaso-active medication and 22--treated with various vaso-active drugs (Hydrosarpan 711, Eleparon, Radecol, Padutin, Trental, etc.).

[Quantitative determination of the mineral content of bone].

The interest shown in bone mineralometry is explained by the great medical and social importance of osteoporosis and the growing potentialities of the methods for its guantitative determination. The possibilities for visual assessment of the conventional X-ray image of the bone are discussed in the reports as well as X-ray morphometry o. the tubular bones and vertebrae, roentgen and photonabsorption densitometry and computer-tomography.

[Characteristics of diabetic osteoarthropathy].

On the base of three observations, derived from a series of systematically followed up diabetics, the authors describe certain rare findings and peculiarities of the diabetic osteoarthropathy, being of diagnostic interest. The parallel X-ray, scintigraphic, functional and thermography investigations are of special significance, wherefrom an enhanced fixation of radionucleids and local hyperthermia in zones, coinciding with the roentgenologically established bone lesions, were found. The importance of the complex dynamic follow up of the osteo-articular changes in the late degenerative syndrome of diabetes is stressed upon.

[Idiopathic osteoporosis at an early age].

Two males, aged 33, with progressive pains in the spine are described as well as with high degree osteoporosis, compressive fractures of several vertebrae and a rapid evolution of the changes. The values of serum calcium and phosphorus as well as alkaline phosphatase proved to be normal. Excretion of calcium and hydroxyproline in urine were also normal, whereas phosphorus excretion was increased.

[Observation of the changes in the locomotor apparatus and calcium-phosphorus metabolism in kidney transplant patients].

Renal function indices were analyzed as well as those of calcium-phosphorus metabolism and the state of bone skeleton in seven patients with renal transplantation. Consideration is given to a grave complication resulting from a long-term treatment with corticosteroids--aseptic osteonecrosis, found in two of the subjects observed and severe cortisone myopathy in one of the patients.

Efficacy of pneumogynecography in the diagnosis of Meyer-Rokitansky-Küster-Hauser syndrome.

Twelve patients with Meyer-Rokitansky-Küster-Hauser syndrome were examined by means of pneumogynecography. The results obtained disclose the great diagnostic value of the method in this disorder.

[Itsenko-Cusing syndrome in hypohyseal adenoma].

A case observed at the Insitute of Endocrinology, Gerontology, and Geriatry is reported with Icenko--Cushing syndrome developed in consequence of hypophyseal adenoma. The telegammatherapy (total focal dose 4760 rads) carried out in the course of one year led to a complete regression of the developed alterations-- elimination of the redistribution of fats, restoration of the face normal colour and oval, nails and hair normalization as well as of cortisolemia and decrease in the osteoporosis degree with consolidation of the pathological fractures. Blood pressure (without hypotensive treatment) within normal values--140/90.