Erratum: Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IPR2 circuit.

[This corrects the article DOI: 10.1016/j.isci.

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IPR2 circuit.

Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca entry into the endoplasmic reticulum (ER) via the ER Ca ATPase pump. This entry is followed by inositol trisphosphate receptor 2 (IPR2)-elicited ER Ca release into the cytosol.