Aggregation-induced emission(AIE)for next-generation biosensing and imaging: A review.

Luminescence technology is a powerful analytical tool for biomedical research as well as for marker detection. Luminescent materials with aggregation-induced emission (AIE) properties have attracted extensive research interest, and their unique luminescence characteristics, biocompatibility, and sensitivity make them useful for the development of fluorescence-turn-on biosensors with superior sensitivity. While numerous reviews have focused on the design of AIEgens, comprehensive summaries on the strategies for biosensor preparation and application fields remain limited.

A compact solid-state high repetition rate trigger based on a spiral generator.

The trigger generator made with a spiral generator (SG) has the advantages of light weight, compact structure, and low cost and has promising applications in the pulsed power field. This paper introduces a compact solid-state high-voltage pulse trigger system based on an improved SG, which has improved repetition rate and lowered the demands for semiconductor switches' maximum current and current rise rate when compared with previous studies. The improvement is achieved by winding outward an additional layer of the passive layer and low-voltage metal strip, which realizes a significant reduction of the peak current and current rise rate of the discharge switch.

Study on a rotational symmetry structure pulse forming network with low-impedance for compact pulse drivers.

A pulse forming network (PFN) is a significant component, contributing a lot to the overall dimension of pulse generators. In order to both reduce the size of PFN and improve the output waveform quality, this paper proposes a compact low-impedance PFN with a rotational symmetry structure. The PFN consists of four groups of Blumlein pulse forming units (PFUs) connected in parallel along the angular direction, and the spline curve structure is applied in each PFU, which achieves a higher space utilization rate.

Analysis of m6A-regulated genes and subtype classification in lupus nephritis.

Background: Lupus nephritis (LN) is the most common and severe clinical manifestation of systemic lupus erythematosus (SLE). N6-methyladenosine (m6A) is a reversible RNA modification and has been implicated in various biological processes. However, the roles of m6A regulators in LN are not fully demonstrated.

An EM-Tracked Approach for Calibrating the 3D Pose of Flexible Endoscopes.

Flexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to simplify the calibration process, we propose an electromagnetic (EM)-tracked calibration approach that does not require any predefined poses of the EM sensor.

Integrative analysis of the association between circadian rhythm and lupus nephritis.

Background: Lupus nephritis (LN) is an autoimmune nephropathy associated with systemic lupus erythematosus. Circadian rhythms are involved in the development of several diseases, especially inflammation-related diseases, but their relationship with LN is unclear.

Methods: This was an integrative bioinformatics study.

Effect of Youthful Blood Environment and Its Key Stem Cell Factor on Renal Interstitial Fibrosis in Elderly Mice.

Introduction: Youthful blood environment was shown to decelerate the aging process of the kidney and to attenuate senile renal fibrosis in a young-old parabiotic animal model; in addition, we identified a stem cell factor (SCF) that is closely linked with the process. This research was to investigate the effect of youthful blood environment on senile renal interstitial fibrosis and the role of SCF.

Methods: We bred SCF receptor c-Kit gene loss-of-function Wps/Wps mice and established a combination mice model that was subjected to unilateral ureteral obstructive (UUO) and parabiotic surgeries.

A compact repetitive high energy-density accelerator HEART-20 based on propylene carbonate pulse forming line.

The development of pulsed power technology requires an electron beam accelerator with high output power and repetitive operation. A compact repetitive electron beam accelerator based on a pulse transformer and a pulse forming line of high permittivity liquid, as an essential type of one, has attracted extensive attention at the present time. In this paper, the development of a compact high energy-density electron beam accelerator, viz.

Effect of Leptin Levels of Type 2 Diabetes Mellitus and Diabetic Complications.

Purpose: To investigate serum leptin levels in patients with type 2 diabetes mellitus (T2DM) and the relationship between leptin levels and T2DM complications and prevalence.

Methods: A total of 355 patients, 282 cases with T2DM and 73 normal controls, were recruited at 1st Medical Centre, Chinese PLA General Hospital (Beijing, China) between November 2013 and July 2014. Levels of serum leptin, biochemical markers and sexual hormones were measured, and clinical characteristics were retrieved through the electronic medical record system.

A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity.

Background: As genetic genetic factors are important in SLE, so screening causative genes is of great significance for the prediction and early prevention in people who may develop SLE. At present, it is very difficult to screen causative genes through pedigrees. The analytical method described herein can be used to screen causative genes for SLE and other complex diseases through pedigrees.

A Novel Ferroptosis-Related lncRNA Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma.

Purpose: Papillary renal cell carcinoma (PRCC) is a common renal cell carcinoma. Recent studies have reported that ferroptosis is involved in the occurrence and development of tumors. Long non-coding RNAs can be used as independent biomarkers for the diagnosis and prognosis of a variety of tumors.

Exploring the Underlying Mechanism of Shenyankangfu Tablet in the Treatment of Glomerulonephritis Through Network Pharmacology, Machine Learning, Molecular Docking, and Experimental Validation.

Purpose: This study aimed to explore the underlying mechanisms of Shenyankangfu tablet (SYKFT) in the treatment of glomerulonephritis (GN) based on network pharmacology, machine learning, molecular docking, and experimental validation.

Methods: The active ingredients and potential targets of SYKFT were obtained through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, the targets of GN were obtained through GeneCards, etc. Perl and Cytoscape were used to construct an herb-active ingredient-target network.

Effects of Simulated Microgravity on the Physiology of and Multiomic Analysis.

Many studies have shown that the space environment plays a pivotal role in changing the characteristics of conditional pathogens, especially their pathogenicity and virulence. However, , a type of conditional pathogen that has shown to a gradual increase in clinical morbidity in recent years, has rarely been reported for its impact in space. In this study, was exposed to a simulated microgravity (SMG) environment in high-aspect ratio rotating-wall vessel bioreactors for 14days, while the control group was exposed to the same bioreactors in a normal gravity (NG) environment.

Low-impedance high-power pulsed generator based on forming line with built-in Tesla transformer.

In order to meet the application needs of gyromagnetic nonlinear transmission lines, a pulsed power generator is required to output short duration pulses with a fast rising edge in high repetitive-rate mode. In this paper, a low-impedance high-power pulsed generator based on the forming line with a built-in Tesla transformer is explored and developed. The generator includes a 14 Ω coaxial forming line, a SF/N gas switch, and a resistive dummy load, which can steadily operate in 100 Hz mode and suits the needs above.

A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma.

Background: GPRIN1 may be a novel tumor regulator, but its role and mechanism in tumors are still unclear.

Methods: First, a pan-cancer correlation analysis was conducted on the expression and prognosis of GPRIN1 based on the data downloaded from The Cancer Genome Atlas (TCGA) database. Second, the Starbase database was used to predict the upstream miRNAs and lncRNAs of GPRIN1, and the expression analysis, survival analysis, and correlation analysis were performed to screen the microRNA (miRNAs)/long non-coding RNAs (lncRNAs) that had a correlation with kidney renal papillary cell carcinoma (KIRP) or lung adenocarcinoma (LUAD).

RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.

Serine is located on chromosome 8q21 and encodes a protein containing a C-terminal caspase activation and recruitment domain (CARD), which is a component of signaling complexes in both the innate and adaptive immune pathways. To estimate the value of RIPK2 in evaluating the prognosis and guiding the targeted therapy for patients with kidney renal clear cell carcinoma (KIRC), we analyzed total 526 KIRC samples from The Cancer Genome Atlas (TCGA) database. Our result showed that RIPK2 was upregulated in KIRC tumor samples compared with normal samples.

Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19.

Background: The rapid outbreak of coronavirus disease 2019 (COVID-19) is a major health concern, in response to which widespread risk factor research is being carried out.

Objective: To discover how physical activity and lifestyle affect the epidemic as well as the disease severity and prognosis of COVID-19 patients.

Methods: This multicenter, retrospective cohort study included 203 adults infected with COVID-19 and 228 uninfected adults in three Chinese provinces, with 164 (80.

Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019.

This cohort study examines the clinical characteristics of men with coronavirus disease 2019 whose semen tested positive for severe acute respiratory syndrome coronavirus 2.

Decreased metabolism and increased tolerance to extreme environments in Staphylococcus warneri during long-term spaceflight.

Many studies have shown that the space environment can affect bacteria by causing a range of mutations. However, to date, few studies have explored the effects of long-term spaceflight (>1 month) on bacteria. In this study, a Staphylococcus warneri strain that was isolated from the Shenzhou-10 spacecraft and had experienced a spaceflight (15 days) was carried into space again.

Genomic characterization of LCT-EC001, an extremely multidrug-resistant strain with an amazing number of resistance genes.

Background: Multidrug resistance is a growing global public health threat with far more serious consequences than generally anticipated. In this study, we investigated the antibiotic resistance and genomic traits of a clinical strain of LCT-EC001.

Results: LCT-EC001 was resistant to 16 kinds of widely used antibiotics, including fourth-generation cephalosporins and carbapenems.

Exogenous biological renal support ameliorates renal pathology after ischemia reperfusion injury in elderly mice.

We established an exogenous biological renal support model through the generation of parabiotic mice. At 72 hours after ischemia reperfusion injury (IRI), the aged mice that received exogenous biological renal support showed significantly higher levels of renal cell proliferation and dedifferentiation, lower levels of renal tubular injury, improved renal function, and a lower mortality than those that did not receive exogenous biological renal support. Using the Quantibody Mouse Cytokine Antibody Array, we found that aged IRI mice that received exogenous biological renal support had an up-regulation of multiple inflammatory related cytokines compared to the group that did not receive exogenous biological renal support.

Increased growth rate and amikacin resistance of Salmonella enteritidis after one-month spaceflight on China's Shenzhou-11 spacecraft.

China launched the Tiangong-2 space laboratory in 2016 and will eventually build a basic space station by the early 2020s. These spaceflight missions require astronauts to stay on the space station for more than 6 months, and they inevitably carry microbes into the space environment. It is known that the space environment affects microbial behavior, including growth rate, biofilm formation, virulence, drug resistance, and metabolism.

Decreased biofilm formation ability of Acinetobacter baumannii after spaceflight on China's Shenzhou 11 spacecraft.

China has prepared for construction of a space station by the early 2020s. The mission will require astronauts to stay on the space station for at least 180 days. Microbes isolated from the International Space Station (ISS) have shown profound resistance to clinical antibiotics and environmental stresses.

Exploration of the involvement of LncRNA in HIV-associated encephalitis using bioinformatics.

Background: HIV-associated encephalitis (HIVE) is one of the common complications of HIV infection, and the pathogenesis of HIVE remains unclear, while lncRNA might be involved it. In this study, we made re-annotation on the expression profiling from the HIVE study in the public database, identified the lncRNA that might be involved in HIVE, and explored the possible mechanism.

Methods: In the GEO public database, the microarray expression profile (GSE35864) of three regions of brain tissues (white matter, frontal cortex and basal ganglia brain tissues) was chosen, updated annotation was performed to construct the non-cording-RNA (ncRNA) microarray data.