The use of growth hormone therapy in adults with Prader-Willi syndrome: A systematic review.

Objective: Despite clear benefits in the management of children with Prader-Willi syndrome (PWS), the role of growth hormone (GH) in adults is unclear. The aim of this study was to conduct a systematic review to evaluate the effects of GH on body composition, bone health and cardiovascular health in adults with PWS.

Design: A systematic computerized literature search of the PubMed database was conducted by two independent reviewers.