Publications by authors named "Diane Umuhoza"
The clinical presentation overlap between malaria and COVID-19 poses special challenges for rapid diagnosis in febrile children. In this study, we collected RNA-seq data of children with malaria and COVID-19 infection from the public databases as raw data in fastq format paired end files. A group of six, five and two biological replicates of malaria, COVID-19 and healthy donors respectively were used for the study.
View Article and Find Full Text PDFThe remarkable features of silk fibroin (SF) from the silkworm () have fueled its application as a candidate biomaterial for tissue regeneration and repair. For an ideal scaffold, the rate of degradation should be synchronized to match the rate of new tissue formation, and tuning this rate is essential, as diverse tissues differ in terms of regeneration period. In this Review, we discuss the factors influencing the degradability of SF, which can vary from days to several months, depending on the state of the raw material, the scaffold preparation process, morphological features, and host factors.
View Article and Find Full Text PDFArticle Synopsis
- Fibroin from silkworms is made up of various polypeptides, including heavy and light chains, but their specific roles in silk processing are still not well understood.
- Researchers created transgenic silkworms to study how these proteins behave in silk glands and cocoon silk by tracking fluorescent fusion proteins.
- Findings revealed that hydrophilic N-terminal domains help prevent premature protein crystallization on micelle surfaces, while C-terminal domains help manage the solubility of large micelles, providing insights that could advance artificial silk production and biomaterials development.
Article Synopsis
- 1-Aminocyclopropane-1-carboxylic acid synthase (ACS) and oxidase (ACO) are key enzymes in fruit ripening, producing ethylene, but research on these genes in mulberry is limited.
- The study identified five ACS genes and two ACO genes from the Morus Genome Database and analyzed their sequences, revealing conservation among ACO proteins across species.
- Expression analysis showed that MaACS genes are predominantly active in mulberry fruit and that MaACO genes exhibit varying expression patterns in different tissues, with both gene families being significantly regulated by abscisic acid (ABA) and ethephon.