Publications by authors named "Diane Lechevalier"
Immune checkpoint inhibitors (ICIs) have become the standard treatment for many types of cancer. After several years of using these therapies, many adverse events related to ICIs have been observed. Dermatologic toxicities such as nonspecific morbilliform rash, vitiligo, Stevens-Johnson syndrome/toxic epidermal necrolysis, and more rarely, lichenoid eruptions have been described in the literature.
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- The study looks at how the environment around tumors, especially in melanoma, can affect how cancer grows.
- Researchers found that certain cells (endothelial cells) can change their role and features due to signals from melanoma cells, a process called EndMT.
- The experiments showed that specific enzymes (NOX1 and NOX2) help control this change, and blocking them can partially reverse the changes caused by the melanoma cells.
This study aims at reporting 11 cases of carpal tunnel syndrome (CTS) occurring in patients on immunotherapy. The increasing use of immune checkpoint inhibitors in oncodermatology is associated with the appearance of immunologic adverse effects linked to nonspecific stimulation of the immune system. CTS has not been reported in this context.
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