Publications by authors named "Diane Le Quang"
Article Synopsis
- A study conducted in France updated the epidemiology of perioperative anaphylaxis, a rare but serious allergic reaction occurring during surgeries, highlighting its changing nature influenced by clinical practices and environment.* -
- Out of 765 cases analyzed, a significant portion (56%) were severe reactions, mainly caused by neuromuscular blocking agents (60%), with antibiotics like cefazolin also being a notable trigger.* -
- The study emphasizes the need for ongoing surveillance of perioperative anaphylaxis, particularly due to the increasing frequency of reactions to antibiotics and the unknown reasons behind cefazolin sensitization.*
Background: Neuromuscular blocking agents (NMBAs) are among the leading cause of perioperative anaphylaxis, and most of these reactions are IgE mediated. Allergic sensitisation induced by environmental exposure to other quaternary ammonium-containing compounds, such as pholcodine, has been suggested. The aim of this study was to assess the relationship between pholcodine exposure and NMBA-related anaphylaxis.
View Article and Find Full Text PDFBackground: Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we are lacking data on burn shock. Our objective was to assess the hydrocortisone-induced transcriptional modulation in severe burn shock, particularly modulation of the immune response.
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