Publications by authors named "Diane Jolley"
Specific retinoid X receptor (RXR) agonists, such as LG100268 (LG268), and the thiazolidinedione (TZD) PPARgamma agonists, such as rosiglitazone, produce insulin sensitization in rodent models of insulin resistance and type 2 diabetes. In sharp contrast to the TZDs that produce significant increases in body weight gain, RXR agonists reduce body weight gain and food consumption. Unfortunately, RXR agonists also suppress the thyroid hormone axis and generally produce hypertriglyceridemia.
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- Bexarotene, an RXR agonist, can lead to significant hypothyroidism in patients with cutaneous T cell lymphoma, but the exact mechanism is not well understood.
- A study using the selective RXR agonist LG100268 on rats showed that it rapidly decreased TSH levels, with total T(4) and T(3) also declining more gradually after treatment.
- The research identified that LG100268 induces hypothyroidism primarily by acutely reducing TSH secretion from the pituitary gland, and this effect is separate from its impact on TSHbeta gene transcription.