Publications by authors named "Diane B M A van Wieren-de Wijer"
Purpose: In epidemiological studies, non-response may introduce bias and limit generalizability. In genetic pharmacoepidemiological research, collection of DNA might be a major reason for non-response. We determined reasons for non-response and compared characteristics of non-responders and responders in a pharmacogenetic case-control study.
View Article and Find Full Text PDFIntroduction: The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension.
Objective: The aim of the study was to determine whether the alpha-adducin 460Trp variant allele modifies the risk-lowering effect of diuretics on myocardial infarction (MI).
Design, Setting And Participants: In a population-based registry of pharmacy records linked to hospital discharge records (PHARMO), we used a nested case-control design.
Objective: To describe the design, recruitment and baseline characteristics of participants in a community pharmacy based pharmacogenetic study of antihypertensive drug treatment.
Setting: Participants enrolled from the population-based Pharmaco-Morbidity Record Linkage System.
Method: We designed a nested case-control study in which we will assess whether specific genetic polymorphisms modify the effect of antihypertensive drugs on the risk of myocardial infarction.
Introduction: The GNB3 C825T polymorphism has been shown to affect lipid parameters, atherosclerosis progression, and incidence of myocardial infarction (MI). Therefore, we assessed whether the effectiveness of statins in reducing the risk of MI was modified by the GNB3 C825T polymorphism.
Methods: In a population-based registry of pharmacy records linked to hospital discharge records (PHARMO), we used a nested case-control design.