Publications by authors named "Diancourt L"

This study reports a botulism outbreak on a pig farm. Clostridium botulinum type C was detected using PCR. The gene encoding the toxin corresponds to a novel type C neurotoxin recently described in a human botulism outbreak, raising the question of its prevalence in pigs and the related risks to humans.

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  • The study focuses on ribotype (RT) 002, linked to severe healthcare-associated infections like colitis, by analyzing the genetic characteristics of 537 genomes associated with MLST sequence type (ST) 8.
  • Researchers sequenced 298 strains from a new European collection, comparing them with a global dataset of 1,437 ST8 genomes, revealing genetic similarity, diverse antimicrobial resistance genes, and an open genomic structure.
  • Results indicate that while ST8 shows low overall variation and stability across different environments, it can still acquire antimicrobial resistance genes, highlighting the need for ongoing surveillance of non-human sources to better understand its epidemiology.
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  • The text discusses a rare case of bacteremia caused by a strain of an anaerobic, spore-forming Gram-positive bacterium associated with severe infections like necrotizing gangrene and gastrointestinal issues.
  • In 2014, a new toxin called BEC was identified, which can lead to acute gastroenteritis in humans; the text highlights a 64-year-old man who developed pneumonia and septic shock, ultimately passing away despite treatment.
  • Whole genome sequencing of the bacteria found in the patient revealed various virulence factors, including the newly discovered BEC toxin, and confirmed a significant genetic diversity among BEC-producing strains.
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Background: Clostridium neonatale was isolated during an outbreak of neonatal necrotizing enterocolitis (NEC) in 2002. C. neonatale was validated as a new species within the genus Clostridium sensu stricto in 2018.

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In September 2023, a severe outbreak of type B botulism with fifteen cases was linked to consumption of canned sardines at a restaurant in Bordeaux, France, during the Rugby World Cup. The cases were from seven countries. One death was recorded.

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has been isolated from the fecal samples of asymptomatic neonates and cases of necrotizing enterocolitis (NEC). Taking advantage of a large collection of independent strains isolated from different spatio-temporal settings, we developed and established a cgMLST scheme for the molecular typing of . Both the cgMLST and cgSNP methods demonstrate comparable discrimination power.

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Article Synopsis
  • In September 2023, a botulism outbreak linked to canned sardines affected 15 people in Bordeaux, France, during the Rugby World Cup.
  • Eight patients from four countries were admitted to the ICU, with six needing invasive mechanical ventilation.
  • The incident emphasizes the need for quick global alerts from health authorities to mitigate the impact of health crises during major international events.
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On 6 July 2018, the Center for Epidemiology and Public Health of the French Armed Forces was informed of an outbreak of acute gastroenteritis among customers of a dining facility at a military base in Brittany, France. A total of 200 patients were reported out of a population of 1700 (attack rate: 12%). The symptoms were mainly lower digestive tract disorders and occurred rapidly after lunch on 5 July (median incubation period: 3.

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is a sporulating Gram-positive anaerobic rod that is considered to be one of the most fastidious and oxygen-sensitive anaerobes. It is a well-known animal pathogen and the cause of bacillary hemoglobinuria primarily in cattle. To date, human infections caused by have been reported in three patients with malignant underlying diseases.

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A Gram-positive, anaerobic coccus isolated from a human surgical site infection was previously shown to belong to an unknown species of the genus Peptoniphilus initially proposed as 'Peptoniphilus nemausus' sp. nov., based on both 16S rRNA gene sequence identity of 97.

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Multidrug resistant (MDR) bacteria are increasingly observed in nosocomial and community-acquired settings. Anaerobes are no exception to this rule, but there are fewer reports of MDR in the scientific literature on anaerobes than there are for other bacteria. In this short case report, we describe the first case of bacteraemia caused by a multidrug-resistant , which produces a carbapenemase encoded by the gene.

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Clostridium tetani produces a potent neurotoxin, the tetanus neurotoxin (TeNT) that is responsible for the worldwide neurological disease tetanus, but which can be efficiently prevented by vaccination with tetanus toxoid. Until now only one type of TeNT has been characterized and very little information exists about the heterogeneity among C. tetani strains.

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Europe is the world's leading tourism destination and is receiving every year travellers from areas with active arbovirus transmission. There is thus a threat of mosquito-borne virus emergence in Europe due to the presence of the invasive mosquito vector . Little attention has been paid about the possible role of indigenous mosquito species as vectors of emerging arboviruses.

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We report 17 draft genomes for 14 unidentified sp. strains closely related in 16S rRNA gene-based phylogeny and type strains of 3 species with the aims of deciphering relationships between related species, evaluating the accuracy of current thresholds for species delineation, and robustly describing new species in the genus.

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type E is a less frequently isolated type and has not previously been reported in France. We have characterized two recent type E isolates, 508.17 from the intestinal content of a calf that died of enterotoxemia, and 515.

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The emergence of SARS-CoV and MERS-CoV, triggered the discovery of a high diversity of coronaviruses in bats. Studies from Europe have shown that coronaviruses circulate in bats in France but this reflects only a fraction of the whole diversity. In the current study the diversity of coronaviruses circulating in western Europe was extensively explored.

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In May 2012, the first authenticated cases of active chikungunya virus infection were detected in Champasak Province, Southern Laos. Analysis of series of human samples and mosquito specimens collected during the outbreak and over the year that followed the emergence enabled the drawing up of a map of the progression of CHIKV and the establishment of a full genetic characterization of the virus.

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We sequenced the first (BCoV) complete genome sequence from France. This BCoV was directly sequenced from a fecal sample collected from a calf in Normandy in 2014.

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Background: The human papillomavirus (HPV) is the causative agent of cervical cancer, which is the leading cancer-related cause of death for women in Sub-Saharan Africa. In 2013, the Gabonese Ministry of Health and the Sylvia Bongo Ondimba Foundation implemented cervical cancer screening programs based on the detection of cancerous lesions by visual inspection with acetic acid and/or Lugol's iodine (VIA/VILI). This pilot study was set up to determine the HPV profile and analyze the nucleotide sequence variation of HPV16 circulating in patients with cervical abnormalities detected by VIA/VILI testing.

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Elizabethkingia anophelis is an emerging pathogen involved in human infections and outbreaks in distinct world regions. We investigated the phylogenetic relationships and pathogenesis-associated genomic features of two neonatal meningitis isolates isolated 5 years apart from one hospital in Central African Republic and compared them with Elizabethkingia from other regions and sources. Average nucleotide identity firmly confirmed that E.

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Introduction: Human angiostrongyliasis (HA) is a neurological helminthic disease caused by the lung worm Angiostrongylus cantonensis. It is suspected in the combination of travel or a residence in an endemic area and eosinophilic meningitis. In Mayotte, an island in the Indian Ocean, cases are rare but regular.

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Bovine coronaviruses (BCoVs) are widespread around the world and cause enteric or respiratory infections among cattle. The current study includes 13 samples from BCoVs collected in Normandy during an 11-year period (from 2003 to 2014), 16 French HCoV-OC43s, and 113 BCoVs or BCoVs-like sequence data derived from partial or complete genome sequences available on GenBank. According to a genotyping method developed previously for HCoV-OC43, BCoVs and BCoVs-like are distributed on three main sub-clusters named C1, C2, and C3.

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