Publications by authors named "Diana-Luz Juarez"
Mitochondrial genome has been used across multiple fields in research, diagnosis, and toxicogenomics. Several compounds damage mitochondrial DNA (mtDNA), including biological and therapeutic agents like the human immunodeficiency virus (HIV) but also its antiretroviral treatment, leading to adverse clinical manifestations. HIV-infected and treated patients may show impaired mitochondrial and metabolic profile, but specific contribution of viral or treatment toxicity remains elusive.
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- Sporadic inclusion body myositis (sIBM) is a common muscle disorder in older adults, linked to mitochondrial dysfunction that may contribute to the disease's development.
- A study analyzed mitochondrial characteristics in 30 sIBM patients compared to 38 matched controls, finding significant mtDNA depletion and reduced activity of mitochondrial respiratory chain complexes in both muscle and blood cells.
- The research suggested that disturbances in mitochondrial dynamics and protein expression were associated with muscle impairment, emphasizing the importance of mitochondrial health for muscle function in sIBM patients.