Publications by authors named "Diana Z Osmanova"
Background: Brain-derived neurotrophic factor (BDNF) is associated with response to antidepressant drugs in mood and anxiety disorders. Prolactin (PRL) is a pituitary hormone with behavioural effects, acting as a neurotrophic factor within the brain and may be involved in antidepressant response.
Objectives: To investigate the relationship between BDNF and PRL genotypes with antidepressant drug response.
Background: Hyperprolactinemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 receptors (DRD2s) on the membranes of lactotroph cells within the pituitary gland. Certain antipsychotic drugs, e.g.
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- The study investigates the role of muscarinic acetylcholine receptors in the development of tardive dyskinesia (TD) among patients with schizophrenia.
- Researchers analyzed data from 472 patients, looking at specific genetic variations in two muscarinic receptor genes and their association with TD symptoms, measured by the Abnormal Involuntary Movement Scale.
- They found a lower prevalence of a particular genetic variant in TD patients, suggesting a potential protective effect, although further analysis with other relevant factors showed that this association might not be statistically significant.
Article Synopsis
- The study examined the role of AKT1 and GSK3B genes in the development of tardive dyskinesia (TD) among patients treated with antipsychotics for schizophrenia.
- Researchers analyzed DNA samples from 449 Siberian patients and found no association between TD and specific polymorphisms in the AKT1 and GSK3B genes.
- The findings suggest that these kinases might not be significant contributors to TD, indicating a need to explore other potential mechanisms for the condition, such as neurotoxicity related to dopamine.
Article Synopsis
- This study investigates the relationship between specific genetic variations (SNPs) in the COMT gene and the development of Levodopa-induced dyskinesia (LID) in Caucasian patients with Parkinson's disease (PD).
- A total of 232 PD patients were analyzed, with 212 receiving Levodopa therapy, and their dyskinesia symptoms were evaluated using a standard movement scale.
- Although some associations were found between certain SNPs and LID, the statistical significance diminished when considering the duration of the disease, suggesting that other factors may complicate the link between these genetic variations and the risk of developing LID.
Article Synopsis
- Antipsychotic drugs can lead to hyperprolactinemia, but this condition was also found in untreated patients with their first episode of schizophrenia, suggesting other underlying factors.
- A study involving 443 schizophrenia patients and 126 healthy controls investigated the genetic polymorphism -1149 G/T in the prolactin gene to see if it was linked to hyperprolactinemia.
- Results showed that patients with hyperprolactinemia had a higher frequency of the G allele and GG genotype compared to those without it, indicating a significant genetic association that remained after accounting for other factors.
Objectives: Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT).
Methods: We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs.