Publications by Diana S Yang

Publications by authors named "Diana S Yang"

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Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization.

Todd R Elworthy Denis J Kertesz Woongki Kim Michael G Roepel Lina Quattrocchio-Setti Diana S Yang

Bioorg Med Chem Lett

April 2004

A series of 7-[(5R)-substituted 2-oxo-1-pyrrolidinyl]-heptanoic acids were prepared, their isomeric purity determined, and pharmacologically evaluated. Lactams with affinity for the EP(4) receptor displayed agonist behavior. The lower side-chain of the lactam template could be substituted to afford ligands (e.

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