Publications by authors named "Diana Rodrigues Pereira"
J Neuroimmunol
March 2020
Article Synopsis
- Cognitive dysfunction in multiple sclerosis (MS) is common and challenging to treat, prompting investigation into potential therapies like dimethyl fumarate.
- In a mouse model of MS, treatment with dimethyl fumarate improved spatial memory performance without causing structural damage to the hippocampus, indicating its neuroprotective effects.
- The improvement in memory was linked to reduced demyelination in the fimbria, a key pathway for hippocampal function, suggesting that dimethyl fumarate can positively impact memory even when treatment starts after significant symptoms like hindlimb paralysis develop.
