Publications by authors named "Diana Perez-Etcheverry"
Understanding the spleen response of Russian sturgeon (Acipenser gueldenstaedtii) dealing with chronic heat stress and Aeromonas hydrophila challenge.
Comp Biochem Physiol Part D Genomics Proteomics
December 2024
Article Synopsis
- Sturgeon aquaculture is rising due to higher global demand, particularly for Russian sturgeon, which is key for caviar production; however, global warming poses a significant challenge due to increased temperatures.
- Research on Russian sturgeon exposed to chronic heat stress (CHS) revealed metabolic changes that weaken immune defenses and raise mortality rates, particularly when they're later challenged with the bacteria Aeromonas hydrophila.
- The study identified various gene expressions affected by CHS, indicating a heat shock response, increased apoptosis, and autophagy in the spleen; notably, even under stress, certain immunoglobulins were upregulated, though without changes in serum IgM levels, suggesting potential cellular aging effects in stressed fish.
Recombinant protein expression for structural and therapeutic applications requires the use of systems with high expression yields. Escherichia coli is considered the workhorse for this purpose, given its fast growth rate and feasible manipulation. However, bacterial inclusion body formation remains a challenge for further protein purification.
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