Bisphosphonates and osteonecrosis of the jaws: Clinical and forensic aspects.

Objective: This manuscript aims to provide a comprehensive review of the current knowledge in the pathophysiology, diagnosis, prevention, and other relevant clinical and forensic aspects of a potentially severe complication known as medication-related osteonecrosis of the jaw (MRONJ) while synthesizing state-of-the-art information on bisphosphonates and introducing a possible differential diagnosis.

Design: An extensive search was conducted in PubMed (U.S.

Biochemical and cellular changes in leukocyte-depleted red blood cells stored for transfusion.

Background: To evaluate biochemical and cellular changes associated with the storage of leukocyte-depleted red blood cells (RBCs).

Methods: We investigated 10 leukocyte-depleted RBC units, randomly chosen from volunteer donors. Every week an aliquot was collected for laboratorial evaluation, which included complete cell blood count, glucose-6-phosphate dehydrogenase (G6PD) activity, extracellular sodium, potassium and pH, membrane-bound hemoglobin (MBH), band 3 profile, and quantification of RBC membrane proteins composition.