Study of naïve and memory cells in a cohort of Egyptian chronic granulomatous disease patients.

Context: Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder caused by inherited defects in the NADPH oxidase complex which may be involved in important pathways that connect innate and adaptive immunity.

Objectives: Characterize the naive and memory compartment of B and T lymphocytes in patients with CGD.

Methods: Twenty CGD patients and twenty healthy controls matched for age and sex were enrolled in this study.