Effect of Abrupt Discontinuation of Antidepressants in Critically Ill Hospitalized Adults.

Objectives: To determine whether discontinuation of chronic antidepressant therapy is associated with a higher risk of antidepressant discontinuation syndrome (ADS) symptoms in patients admitted to the intensive care unit (ICU) when compared with those who were continued on therapy and to identify factors associated with increased risk of ADS in this population.

Design: Single-center retrospective observational cohort study.

Setting: ICUs in a tertiary care hospital.