Publications by authors named "Diana Maria Ciuculete"
Article Synopsis
- Statins may increase the risk of insomnia, but the connection is debated, and it’s unclear if the risk comes from statins themselves, cholesterol reduction, or other factors.
- This study explored the link between statin use, genetic markers for cholesterol control, and insomnia risk among a large group of people in the UK Biobank.
- Results indicated that statin users had a higher risk of insomnia compared to non-users, while specific genetic variants (in genes HMGCR and PCSK9) showed varied associations with insomnia risk.
Perceived stress is related to lower blood pressure in a Swedish cohort.
Scand J Public Health
June 2023
Aims: General psychosocial stress and job strain have been related to blood pressure (BP) with conflicting results. This study sought to explore the contribution of several lifestyle factors in the relation between general psychosocial stress, job strain and BP.
Methods: This cross-sectional study investigated the association of general stress and job strain with systolic BP (SBP) and diastolic BP in a sample of 9441 employed individuals from the EpiHealth cohort.
Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur in the injured human brain and be implicated in the neurodegenerative aftermath of TBI.
View Article and Find Full Text PDFJob-related stress has been associated with poor health outcomes but little is known about the causal nature of these findings. We employed Mendelian randomisation (MR) approach to investigate the causal effect of neuroticism, education, and physical activity on job satisfaction. Trait-specific genetic risk score (GRS) based on recent genome wide association studies were used as instrumental variables (IV) using the UK Biobank cohort (N = 315,536).
View Article and Find Full Text PDFHypersexual disorder (HD) was proposed as a diagnosis in the DSM-5 and the classification 'Compulsive Sexual Behavior Disorder' is now presented as an impulse-control disorder in ICD-11. HD incorporates several pathophysiological mechanisms; including impulsivity, compulsivity, sexual desire dysregulation and sexual addiction. No previous study investigated HD in a methylation analysis limited to microRNA (miRNA) associated CpG-sites.
View Article and Find Full Text PDFArticle Synopsis
- Metformin is a common medication for controlling blood sugar that may also affect DNA methylation in various diseases, highlighting its potential benefits beyond diabetes treatment.
- A study examined how short-term metformin administration influenced DNA methylation profiles in healthy participants, identifying 125 differentially methylated regions, particularly in genes linked to energy regulation, inflammation, tumor development, and neurodegenerative diseases.
- The results suggest that DNA methylation may play a role in metformin's therapeutic effects, paving the way for further research into its mechanisms and potential new applications.
Background: Studies of epigenetics and transcriptional activity in adolescents may provide knowledge about possible preventive strategies of depression.
Methods: We present a methylome-wide association study (MWAS) and cohort validation analysis of depression in adolescents, in two separate cohorts: discovery (n=93) and validation data set 1 (n=78). The genome-wide methylation pattern was measured from whole blood using the Illumina 450K array.