Publications by authors named "Diana Maria Anastasiu"
Article Synopsis
- The study explores the molecular mechanisms behind Down syndrome, focusing on the expression levels of specific microRNAs (miR-99a) located on chromosome 21 in amniotic fluid from pregnancies with Down syndrome.
- It utilizes qRT-PCR methods to compare microRNA levels in samples from Down syndrome and typical pregnancies, identifying a notable up-regulation of mature miR-99a in female fetuses with Down syndrome.
- The findings suggest that the alteration in miR-99a expression may affect critical signaling pathways linked to heart development, potentially contributing to cardiac defects observed in female patients with Down syndrome.
In recent years, identification of new sources of adult stem cells developed rapidly, pursuing to find easily available tissues, which will give rise to homogenous stem cells populations. Up to present, bone marrow-derived mesenchymal stem cells (BM-MSCs) are unanimously considered to fulfill the criteria for being used in clinical settings, but adipose stem cells, placental and umbilical cord stem cells, and other tissue-derived stem cells are making their way to being used at least in autologous transplantation. We isolated cellular populations from placental tissue and umbilical cord using the explants method.
View Article and Find Full Text PDF