Publications by authors named "Diana Lee"

Background: This study aimed to investigate which basic psychological needs profile, based on different levels of autonomy, competence, and relatedness, could exhibit higher student engagement and favorable attitudes toward interprofessional education (IPE).

Methods: A total of 341 undergraduate and postgraduate health and social care students enrolled in an IPE simulation participated in this study. Data were analyzed using a person-centered approach using a two-step cluster analysis, multiple analysis of variance, and bootstrapped independent t-tests.

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Treprostinil Use in the NICU.

Adv Neonatal Care

December 2024

Background: Treprostinil is a prostacyclin analogue that is frequently used in the pediatric and adult population to treat pulmonary hypertension; however, it is not often a drug of choice for patients in the neonatal intensive care unit (NICU).

Purpose: To evaluate the efficacy of treprostinil as a treatment for pulmonary hypertension of the neonate.

Data Sources: Electronic databases such as PubMed, CINAHL, and Embase were used for this literature review.

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Background: Interprofessional education (IPE) incorporates healthcare students from various disciplines to learn with, about, and from one another, aiming to foster effective collaboration. However, the factors that promote these collaboration outcomes remain elusive. Recognizing this knowledge gap, this study utilizes self-determination theory applied in a ten-day IPE programme.

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Objective: To determine the utility of computed tomography (CT) and magnetic resonance imaging (MRI) in cochlear implant candidates.

Study Design: Retrospective case review.

Setting: Tertiary referral hospital.

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Article Synopsis
  • Monovalent and bivalent COVID-19 vaccines containing the Omicron XBB.1.5 variant were approved for use during the 2023-2024 immunization season and are currently undergoing evaluation in a phase 2/3 study.
  • Among participants who previously received previous vaccine doses, those who received the monovalent vaccine showed greater increases in neutralizing antibodies against various SARS-CoV-2 variants compared to those who received the bivalent vaccine.
  • The results indicate that the XBB.1.5 mRNA vaccines generate strong immune responses against newer variants, validating the update of COVID-19 vaccines to include the XBB.1.5 spike protein.
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Substandard and falsified (SF) medical products pose a major threat to public health and socioeconomic development, particularly in low- and middle-income countries. In response, public education campaigns have been developed to alert consumers about the risks of SF medicines and provide guidance on 'safer' practices, along with other demand- and supply-side measures. However, little is currently known about the potential effectiveness of such campaigns while structural constraints to accessing quality-assured medicines persist.

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  • - A new database has been created containing data on approximately 78,000 candidates from 57,000 local electoral contests in the U.S. over the past 30 years.
  • - It covers seven different types of local political offices in medium and large cities and counties, providing a comprehensive public resource for understanding local elections.
  • - The database includes detailed partisan and demographic information about candidates, along with election outcomes, enabling more research into representation and local government elections.
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The management of periprosthetic fractures remains challenging and controversial. There continues to be a significant burden of disease and substantial resource implications associated with fractures following total joint arthroplasty. Achieving consensus opinions regarding the prevention and treatment of this problem has important implications given the profound effect on patient outcomes.

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  • Choline acetyltransferase (ChAT) helps make a chemical called acetylcholine that can reduce inflammation in the body, especially through the vagus nerve.
  • Scientists tested if ChAT in the blood changes during inflammation and if it can help control the release of chemicals that cause inflammation.
  • They found that ChAT levels in mice increased after inflammation and that giving ChAT could lower inflammation, suggesting it might be useful as a treatment for inflammatory diseases in humans.
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  • The study explores new mRNA vaccine strategies to enhance effectiveness against COVID-19, focusing on specific protein domains of the virus instead of the full-length spike protein.
  • The candidate vaccine mRNA-1283, combining the N-terminal domain and receptor binding domain, shows better antigen expression, stronger antibody responses, and improved stability compared to existing vaccines.
  • In animal tests, mRNA-1283 elicits equal or greater immune protection against various COVID-19 variants, supporting its advancement to clinical trials for further evaluation.
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Background And Objective: The impact of anti-sepsis-anesthesia sequence in intravitreal injection (IVI)-associated endophthalmitis is unknown. We compared outcomes of patients who had 10% topical povidone-iodine before or after 2% topical lidocaine gel during IVIs.

Patients And Methods: A retrospective study of IVIs in nine clinical sites was undertaken.

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Introduction: Reporting is an essential component of efforts to combat the distribution and circulation of substandard and falsified (SF) medical products worldwide. However, little is known about why health care professionals (HCPs) do not report suspect products to the national medicine regulatory authority (NMRA) and what measures might address this. This pilot study aimed to assess the utility of a smartphone application for reporting SF medical products in Tanzania and Indonesia.

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Objective: The length of hospital stay (LOS) is a proxy of asthma exacerbation severity and healthcare cost. The study aims to estimate the effect of ambient air pollution on pediatric asthma LOS in the Bronx, NY.

Methods: A total of 1,920 children admitted to the hospital in Bronx, NY due to asthma during 2017-2019 period were included in the study.

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Objective: To test and adapt the Information-Motivation-Behavioral Skills (IMB) model in explaining medication adherence for older patients with multimorbidity.

Methods: Older patients with at least three chronic conditions (N = 254) were recruited from community health centers in Changsha, China. All participants completed a self-administrated questionnaire assessing adherence information, personal motivation, social motivation, behavioral skills, medication adherence, depressive symptoms, medication treatment satisfaction, treatment burden, and disease burden.

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Purpose: To report a rare case of a solitary fibrous tumor (SFT) of the lacrimal sac and discuss considerations for management of similar cases.

Observations: We present the case of a 41-year-old woman who presented with a primary lacrimal sac SFT for which she underwent en-bloc surgical resection. We discuss management options for SFTs and our surgical approach for this case: bilobed flap reconstruction of the medial canthus and inferior orbit.

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Background: Subconcussive blast exposure during military training has been the subject of both anecdotal concerns and reports in the medical literature, but prior studies have often been small and have used inconsistent methods.

Methods: This paper presents the methodology employed in INVestigating traIning assoCiated blasT pAthology (INVICTA) to assess a wide range of aspects of brain function, including immediate and delayed recall, gait and balance, audiologic and oculomotor function, cerebral blood flow, brain electrical activity and neuroimaging and blood biomarkers.

Results: A number of the methods employed in INVICTA are relatively easy to reproducibly utilize, and can be completed efficiently, while other measures require greater technical expertise, take longer to complete, or may have logistical challenges.

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Article Synopsis
  • * Researchers tested two new bivalent vaccines (mRNA-1273.214 and mRNA-1273.222) in mice and found they produced stronger antibody responses against Omicron variants compared to the original vaccine.
  • * Administering these bivalent vaccines as boosters significantly improved immune protection and reduced lung infection severity in mice, highlighting their potential effectiveness against circulating strains.
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  • The emergence of SARS-CoV-2 variants in the Omicron lineage has led to reduced vaccine effectiveness and ongoing virus transmission due to the spike protein's ability to evade antibodies.
  • Researchers evaluated two bivalent vaccines that include mRNAs for spike proteins from both the original virus and recent variants (BA.1 or BA.4/5) and found they produced stronger immune responses in mice compared to existing monovalent vaccines.
  • When used as a booster after initial vaccination, these bivalent vaccines not only generated a more robust antibody response but also provided greater protection against BA.5 infections and reduced inflammation in the lungs.
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Objective: To assess the association between the Youth Pediatric Symptom Checklist-17 (YPSC-17) and adolescents' reports of ever having sex and with having positive testing results for sexually transmitted infections (STIs).

Methods: Analyzed electronic data from primary care clinics for 27,901 adolescents aged 13-17 years with responses to the YPSC-17 and urine screen results for gonorrhea/chlamydia.

Results: On the YPSC-17 in total 8.

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Article Synopsis
  • Researchers developed a new mRNA vaccine, mRNA-1283, targeting specific spike protein domains of the virus responsible for COVID-19.
  • This vaccine demonstrated enhanced antigen expression, antibody responses, and stability when stored in refrigerated conditions compared to the existing mRNA-1273 vaccine.
  • In preclinical tests, mRNA-1283 provided similar or better immune protection against various COVID-19 variants in mice, indicating its potential for human clinical trials.
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Objective: To compare the incidences of early and late-onset neonatal sepsis, including group B streptococcus (GBS) and Escherichia coli (E. coli) before and after implementation of universal screening and intrapartum antibiotics prophylaxis (IAP).

Design: Retrospective cohort study.

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Article Synopsis
  • The rise of SARS-CoV-2 in 2019 prompted the creation of numerous vaccines, with several now approved for human use.
  • Monitoring how well these vaccines generate antibody responses against new variants is crucial for shaping public health strategies.
  • Research indicates that neutralizing antibody responses in vaccinated mice are not as effective or representative as those in humans or non-human primates, highlighting possible limitations of using mice in these studies.
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Background: Older people with multimorbidity are usually required to manage multiple medications and complex medication regimens. However, clinical guidelines for medication management almost entirely focus on a single disease. Further research is needed to assess the efficacy of medication self-management interventions for older people with multimorbidity.

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Background: The number of patients awaiting organ transplantation is high, particularly in Pediatrics, in which available organs are scarce. To maximize organ donation opportunities and to provide quality end-of-life care, clinicians from all professions must be familiar with the process. There continues to be important gaps in core competencies regarding organ donation, including donor criteria and eligibility, timing of referral to organ procurement organizations, neurological determination of death, donation after cardiocirculatory death, and donor management.

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