Challenges in Conducting Clinical Trials for Preeclampsia.

Purpose Of Review: To review recent data describing the challenges and innovations in therapeutic research focused on the prevention and treatment of preeclampsia.

Recent Findings: Pregnant individuals have traditionally been excluded from therapeutic research, resulting in a paucity of innovation in therapeutics for pregnancy-specific medical conditions, especially preeclampsia. With the increased awareness of maternal morbidity and mortality, there is significant interest among researchers to expand therapeutic research in pregnancy.

Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.

Aim: To show that depletion of pancreatic macrophages impairs gestational beta cell proliferation and leads to glucose intolerance.

Materials And Methods: Genetic animal models were applied to study the effects of depletion of pancreatic macrophges on gestational beta-cell proliferaiton and glucose response. The crosstalk between macrophages and beta-cells was studied in vivo using beta-cell-specific extracellular-signal-regulated kinase 5 (ERK5) knockout and epidermal growth receptor (EGFR) knockout mice, and in vitro using a co-culture system.