Publications by authors named "Diana Iarossi"
Article Synopsis
- * It finds that mutations in complex I genes are mutually exclusive with IDH1 mutations but not with IDH2 mutations, indicating a unique relationship that affects how the cancer cells metabolize nutrients.
- * The research highlights that IDH1 mutations create a specific weakness in metabolism, making IDH1-mutant cells more sensitive to treatments that target complex I, revealing potential new therapy strategies for AML patients.
Acute myeloid leukemia (AML) is an aggressive malignancy where despite improvements in conventional chemotherapy and bone marrow transplantation, overall survival remains poor. Sphingosine kinase 1 (SPHK1) generates the bioactive lipid sphingosine 1-phosphate (S1P) and has established roles in tumor initiation, progression, and chemotherapy resistance in a wide range of cancers. The role and targeting of SPHK1 in primary AML, however, has not been previously investigated.
View Article and Find Full Text PDFAberrant activation of β-catenin is a common event in AML and is an independent predictor of poor prognosis. Although increased β-catenin signaling in AML has been associated with oncogenic translocation products and activating mutations in the FLT3R, the mechanisms that activate β-catenin in AML more broadly are still unclear. Here, we describe a novel link between IL-3 signaling and the regulation of β-catenin in myeloid transformation and AML.
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