Publications by authors named "Diana H Rosas"
Brain amyloid and the transition to dementia in Down syndrome.
Alzheimers Dement (Amst)
November 2020
Article Synopsis
- Down syndrome (DS) patients have a heightened risk of developing Alzheimer's disease (AD) due to the buildup of amyloid beta (Aβ) in the brain over their lifetime.
- A study monitored 19 nondemented individuals with DS for 4 years using brain scans to identify Aβ distribution and its link to future dementia conversion.
- Results showed that specific brain regions, especially in the prefrontal and superior frontal cortices, could help predict which individuals with DS would transition to dementia.
Down syndrome: Distribution of brain amyloid in mild cognitive impairment.
Alzheimers Dement (Amst)
April 2020
Introduction: Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI-DS) and test these hypotheses using cross-sectional and longitudinal data.
Methods: 18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze amyloid burden in 58 participants clinically classified as cognitively stable (CS) or MCI-DS and 12 longitudinal CS participants.