Purpureocillium roseum sp. nov. A new ocular pathogen for humans and mice resistant to antifungals.

Background: Infectious keratitis is the main cause of preventable blindness worldwide, with about 1.5-2.0 million new cases occurring per year.

Microscopic characterization of biofilm in mixed keratitis in a novel murine model.

Purpose: To report the characterization and analysis of the biofilm formation in mixed keratitis induced by the coinfection of Staphylococcus aureus and Fusarium falciforme in a novel murine model.

Methods: Clinical ocular microbial isolates and female BALB/c mice were used to develop the murine model. Immunosuppression was achieved with cyclophosphamide and methylprednisolone.