Publications by authors named "Diana F Grigoletto"
Fungi in the genus Trichoderma are notorious producers of secondary metabolites with diverse applications, such as antibacterial, antifungal, and plant growth-promoting properties. Peptaibols are linear peptides produced by such fungi, with more than 440 compounds described to date, including tricholongins, longibrachins, trichobrachins, and trichovirins. Peptaibols are synthesized by non-ribosomal peptide synthetases and they have several biological activities.
View Article and Find Full Text PDFFungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance, new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery.
View Article and Find Full Text PDFArticle Synopsis
- Actinobacteria, particularly from Amazon guarana soil, can produce valuable antimicrobial compounds, making them interesting for biotechnological applications.
- Researchers isolated around 100 actinobacteria strains and identified a new cyclic peptide called gloeosporiocide from Streptomyces morookaense AM25.
- Gloeosporiocide showed significant antifungal activity against the pathogen Colletotrichum gloeosporioides, indicating the potential of these actinobacteria as biocontrol agents and sources of new agricultural compounds.