Publications by authors named "Diana Dang"
Offspring exposed in utero to maternal diabetes exhibit long-lasting insulin resistance, though the initiating mechanisms have received minimal experimental attention. Herein, we show that rat fetuses develop insulin resistance after only 2-day continuous exposure to isolated hyperglycemia starting on gestational day 18. Hyperglycemia-induced reductions in insulin-induced AKT phosphorylation localized primarily to fetal skeletal muscle.
View Article and Find Full Text PDFObjective: To assess the accuracy of body mass index (BMI) as a measure of obesity compared with percent body fat (%BF) directly measured by dual energy x-ray absorptiometry among retired football players.
Methods: The level of agreement between BMI and %BF as measures of obesity was assessed by sensitivity, specificity, and the kappa statistic among 129 retired football players. Logistic regression was used to investigate the association between obesity and selected comorbidities.
Background: Complex but common maternal diseases such as diabetes and obesity contribute to adverse fetal outcomes. Understanding of the mechanisms involved is hampered by difficulty in isolating individual elements of complex maternal states in vivo. We approached this problem in the context of maternal diabetes and sought an approach to expose the developing fetus in vivo to isolated hyperglycemia in the pregnant rat.
View Article and Find Full Text PDFBackground: Cell-free DNA reflects both normal and tumor-derived DNA released into the circulation through cellular necrosis and apoptosis. The authors sought to determine the role of preoperative total plasma cell-free DNA levels in predicting clinical outcome in patients with ovarian cancer.
Methods: After institutional review board consent, DNA was extracted from plasma of 164 women with invasive epithelial ovarian carcinoma (EOC), 49 with benign ovarian neoplasms, and 75 age-matched controls.