Publications by authors named "Diana Cezarina Petrescu"
This study investigates the combined treatment of secukinumab (SECU) and magnolol (MAGN) in a mouse model of LPS-induced ALI overlapped with allergic pulmonary inflammation, aiming to better understand the mechanism behind this pathology and to assess the therapeutic potential of this novel approach in addressing the severity of ALI. The combined treatment reveals intricate immunomodulatory effects. Both treatments inhibit IL-17 and promote M2 macrophage polarization, which enhances anti-inflammatory cytokine production such as IL-4, IL-5, IL-10, and IL-13, crucial for lung repair and inflammation resolution.
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- Neutrophils play a significant role in severe asthma and acute lung injury (ALI) through IL-17 stimulation, promoting an oxidative environment.
- The study compared the effects of Secukinumab (SECU) with Dexamethasone (DEXA) in mice with asthma exacerbated by LPS, focusing on various immune response cytokines.
- Results showed that both treatments altered cytokine levels, with SECU uniquely inhibiting IL-5 and decreasing Th17 responses, while DEXA had different effects on Th1 and Th2 cytokines.
Purpose: For the analysis of erythromycin (ER) in topical pharmaceutical forms we developed a high performance liquid chromatography dosage method (HPLC) greatly improved over the method formalized by the European Pharmacopoeia 5th ed.
Materials And Methods: The work conditions for using a chromatography column with C18 stationary phase were established as follows: optimal column temperature, 45 degrees C; the mobile phase consisted of a mixture of 0.001 M disodium phosphate solution : acetonitrile in the ratio 20:80, volume of sample injected 20 μL, injection rate 1 mL/min and spectrum was recorded at λ = 200 nm.