Genetic variants in triglyceride metabolism genes among individuals with hypertriglyceridemia in Colombia.

Background: The genetic substrate of severe hypertriglyceridemia (sHTG) in Latin America is insufficiently understood.

Objective: To identify genetic variants in genes related to triglyceride (TG) metabolism among adults with sHTG from Colombia.

Methods: In individuals with plasma TG≥880 mg/dL at least once in their lifetime, we amplified and sequenced all exons and intron/exon boundaries of the genes LPL, APOC2, APOA5, GPIHBP1 and LMF1.