Publications by authors named "Diana Bernardo"
Article Synopsis
- - Atopic dermatitis (AD) is a widespread chronic skin condition, mainly affecting kids, caused by a mix of genetic and environmental factors that disrupt skin barriers and immune function, particularly through the action of cytokines like IL-13.
- - New treatments are urgently needed for moderate-to-severe AD, and recent phase III trials show that IL-13 inhibitors like tralokinumab and lebrikizumab are safe and effective, with tralokinumab now available in both Europe and the USA.
- - Other IL-13 targeted therapies, like cendakimab (which is promising from phase II trials) and eblasakimab (currently in phase II after successful phase I results), are under investigation and may
Article Synopsis
- - The study focused on Generalized Pustular Psoriasis (GPP), a rare and serious skin condition, examining its course, treatment approaches, and how often patients used healthcare services in Portugal from 2002 to 2023.
- - It assessed 59 adult patients, revealing that most had a history of another psoriasis type and faced significant health issues, with 64% requiring hospitalization and many experiencing severe symptoms such as fever and high white blood cell counts.
- - Despite treatment, 98% of patients had at least one flare-up, and only a small number showed improvement by the study's end, indicating a need for better understanding and new treatment options to alleviate the disease's impact.
Generalized pustular psoriasis (GPP) is a rare but severe skin inflammatory disorder characterized by the eruption of widespread sterile neutrophilic pustules, often accompanied by systemic inflammation. Given its life-threatening potential, GPP requires prompt accurate diagnosis and effective treatment, but its rarity and relapsing-remitting nature pose challenges in performing large-scale randomized controlled clinical trials. Established international guidelines are currently lacking and management guidance often follows that for plaque psoriasis.
View Article and Find Full Text PDFIntroduction: There is a linear association between pregestational body mass index (BMI) and almost all adverse pregnancy outcomes. Pregnancy is "a window of opportunities" in terms of changing behavior and improving awareness of healthy living. The proper assessment of physical activity levels, during pregnancy, determines trends, health benefits, and their effects over time.
View Article and Find Full Text PDFLebrikizumab for the Treatment of Moderate-to-Severe Atopic Dermatitis.
Am J Clin Dermatol
September 2023
Article Synopsis
- * Interleukin-13 (IL-13) is a key factor in AD's development, leading to skin barrier issues, inflammation, and itch; targeted therapies such as lebrikizumab focus on blocking IL-13 to help manage the condition.
- * Recent trials show that lebrikizumab is effective for moderate-to-severe AD, improving symptoms with a good safety profile, although more long-term data and comparisons with other treatments are needed to establish its role in therapy.
Effectiveness of a structured exercise intervention in gestational weight gain in pregnant women with overweight and obesity: A systematic review with meta-analysis.
Int J Gynaecol Obstet
September 2023
Objectives: To assess the effectiveness of exercise interventions during pregnancy in managing gestational weight gain (GWG), excessive GWG, gestational diabetes (GD), hypertensive disorders, 2-h post-oral glucose tolerance test (OGTT), and birth weight in pregnant women with overweight/obesity (OW/OB).
Methods: The search strategy was conducted in five electronic databases, restricting to articles published within the past 10 years. Randomized controlled trials comparing exercise intervention with usual prenatal care in pregnant women with OW/OB were considered.
Comparison of the Portuguese Version of the Pregnancy Physical Activity Questionnaire (PPAQ) with Accelerometry for Classifying Physical Activity among Pregnant Women with Obesity.
Int J Environ Res Public Health
January 2023
In recent years, the number of pregnant women with obesity has increased exponentially; thus, it is important to evaluate and characterize the physical activity levels of this specific group. The aim of this study is to evaluate the reliability and validity of the Portuguese version of the Physical Activity and Pregnancy Questionnaire and Pregnancy Questionnaire in pregnant women with obesity and to classify physical activity using the Physical Activity and Pregnancy Questionnaire and accelerometry. An analytical observational study was carried out between May and August of 2019 at the University Hospital Center of São João, with a sample of 31 pregnant women with obesity (30.
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