Publications by authors named "Diana Badenes Bonet"
Background: Overnight desaturation predicts poor prognosis across interstitial lung diseases (ILDs). The aim of the present study was to investigate whether nocturnal desaturation is associated with pulmonary vasculopathy and mortality.
Methods: A retrospective single centre study of 397 new ILD patients was carried out including patients with idiopathic pulmonary fibrosis (IPF) (n=107) and patients with non-IPF fibrotic ILD (n=290).
Article Synopsis
- Chronic thromboembolic pulmonary disease (CTEPD) includes ongoing pulmonary vascular blockages that can limit function, and this study aimed to assess how often these defects and chronic thromboembolic pulmonary hypertension (CTEPH) occur in COVID-19 patients after a pulmonary embolism (PE) within a two-year span.
- A total of 133 hospitalized COVID-19 patients with PE were observed over two years, with assessments for residual thrombotic defects and their overall health, revealing that 18% had ongoing thrombotic issues and CTEPD incidence was low at 0.75%.
- Key risk factors for persistent defects included older age, higher incidence of hypertension, elevated D-dimer and NT-proBN
Persistent Respiratory Failure and Re-Admission in Patients with Chronic Obstructive Pulmonary Disease Following Hospitalization for COVID-19.
Int J Chron Obstruct Pulmon Dis
November 2023
Background: Chronic obstructive pulmonary disease (COPD) has been associated with worse clinical evolution/survival during a hospitalization for SARS-CoV2 (COVID-19). The objective of this study was to learn the situation of these patients at discharge as well as the risk of re-admission/mortality in the following 12 months.
Methods: We carried out a subanalysis of the RECOVID registry.
Article Synopsis
- The study investigates the long-term mortality rates associated with COVID-19 and community-acquired pneumonia (CAP) in patients who were hospitalized and later discharged.
- It utilizes a retrospective analysis of two cohorts, applying Bayesian logistic regression to control for confounding factors while assessing mortality outcomes after one year.
- Findings suggest that both types of pneumonia have comparable long-term mortality rates, with no significant difference after adjustments, indicating a low probability of distinguishing between them based on mortality risk.
Background: The post-acute sequelae of SARS-CoV-2 (PASC) infection have caused a significant impact on our health system, but there is limited evidence of approved drugs focused on its prevention. Our objective was to identify risk factors that can determine the presence of PASC, with special attention to the treatment received in the acute phase, and to describe the profile of persistent symptoms in a multidisciplinary Post-Coronavirus Disease-19 (COVID-19) Unit.
Methods: This one-year prospective observational study included patients following an acute COVID-19 infection, irrespective of whether they required hospital admission.
Article Synopsis
- The study investigates how various factors, including muscle strength and symptoms of anxiety and depression, influence physical activity (PA) in patients with idiopathic pulmonary fibrosis (IPF) and their progression over 12 months.
- It was found that lower muscle strength, fewer steps taken, and higher depression levels are linked to reduced daily physical activity.
- Additionally, patients who decreased their activity over the year had a significantly lower survival rate compared to those who maintained or increased their activity levels.
Background: Supplemental oxygen delivered with standard oxygen therapy (SOT) improves exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Although high-flow nasal cannula oxygen therapy (HFNC) improves oxygenation in other respiratory diseases, its impact on exercise performance has never been evaluated in IPF patients. We hypothesized that HFNC may improve exercise capacity in IPF subjects compared to SOT.
View Article and Find Full Text PDFIntroduction: Idiopathic pulmonary fibrosis (IPF) is progressive and irreversible. Some discrepancies about IPF staging exists, especially in mild phases. Forced vital capacity (FVC) higher than 80% has been considered early or mild IPF even for the design of clinical trials.
View Article and Find Full Text PDFWhile the incidence of thrombotic complications in critically ill patients is very high, in patients under non-invasive respiratory support (NIS) is still unknown. The specific incidence of thrombotic events in each of the clinical scenarios within the broad spectrum of severity of COVID-19, is not clearly established, and this has not allowed the implementation of thromboprophylaxis or anticoagulation for routine care in COVID-19. Patients admitted in a semi-critical unit treated initially with NIS, especially Continuous-Positive Airway Pressure (CPAP), were included in the study.
View Article and Find Full Text PDFBackground And Objective: The relationship between IPF development and environmental factors has not been completely elucidated. Analysing geographic regions of idiopathic pulmonary fibrosis (IPF) cases could help identify those areas with higher aggregation and investigate potential triggers. We hypothesize that cross-analysing location of IPF cases and areas of consistently high air pollution concentration could lead to recognition of environmental risk factors for IPF development.
View Article and Find Full Text PDFUnlabelled: Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout the exposed lung.
Objective: To analyze whether the most prevalent mutations observed in ADC can also be observed in the non-neoplastic lung tissue, as well as the short-term prognosis implications of this finding.
Background: Vertebral compression fractures (VCF) are common in COPD patients, with osteoporosis being the main cause. The clinical impact of VCF derives mostly from both pain and chest deformity, which may lead to ventilatory and physical activity limitations. Surprisingly, the consequences of VCF on the quality outcomes of hospital care are poorly known.
View Article and Find Full Text PDFIntroduction: Mediastinal tuberculosis (TB) is rare and a diagnostic challenge. Transbronchial needle aspiration guided by endoscopic ultrasonography (EBUS-TBNA) is an essential tool for staging and diagnosing patients with lung cancer but to date there are no studies in our environment evaluating its efficacy in mediastinal TB.
Methods: Patients with a final diagnosis of isolated intrathoracic tuberculous lymphadenitis over a 6-year period were included.