The interactions of polarographic measurements of oxygen tension and histological grade in human glioma.

Purpose: The purpose of this study is to investigate the implications of hypoxia and histological grade for survival in patients with gliomas.

Materials And Methods: Tissue oxygen tension was measured intraoperatively using an Eppendorf pO2 Histograph. Survival was calculated from the date of the Eppendorf study to the date of last follow-up.

Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial.

Purpose: Previous randomized trials have shown a benefit with concurrent use of the hypoxic cell cytotoxin mitomycin C (MC) and radiation (RT) in the management of squamous cell cancer of the head and neck (SCCHN). We conducted a randomized trial comparing MC with porfiromycin (POR) in combination with RT in the management of SCCHN.

Methods And Materials: Between 1992 and 1999, 128 patients with SCCHN were enrolled in this prospective randomized trial.