Publications by authors named "Diana A Kondinskaia"
Article Synopsis
- Synthetic cationic polymers are effective antibacterial agents, but their mechanisms of action are not well understood; molecular dynamics simulations were used to study their interactions with bacterial membranes.
- The binding of these polymers to anionic membranes can neutralize the membrane's charge, altering the surrounding water structure and releasing counterions, with some polymers even leading to overcharging.
- The properties of the polymers, such as charge and architecture, play a significant role in their effectiveness, indicating that optimizing these characteristics could enhance their antimicrobial potential.
Synthetic cationic polymers represent a promising class of delivery vectors for gene therapy. Here, we employ atomistic molecular dynamics simulations to gain insight into the structure and properties of complexes of DNA with four linear polycations: polyethylenimine (PEI), poly-l-lysine (PLL), polyvinylamine (PVA), and polyallylamine (PAA). These polycations differ in their polymer geometries, protonation states, and hydrophobicities of their backbone chains.
View Article and Find Full Text PDF