Publications by authors named "Dian-jun Wang"

Objective: To evaluate the schistosomiasis control effect of the comprehensive measures that focused on beachland smoothing and tillage cultivation in Tieban Marshland, Wuhan Section of the Yangtze River.

Methods: From 2011 to 2015, before and after the comprehensive control, the snail situations in Tieban Marshland were investigated in spring annually, and the residents aged 6-65 years in Huayuan Community which was next to the marshland were examined to understand their schistosome infection status. In late July, 2014, the sentinel mouse surveillance was carried out.

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Objective: Mixed endometrial stromal and smooth muscle tumor (MESSMT)-a rare mesenchymal uterine tumor of the uterus with atypical clinical symptoms-is susceptible to misdiagnosis and missed diagnosis. We report a case of a disseminated MESSMT with intravenous and intracardiac extensions treated with staging surgery and review previously documented cases of such tumors with intracardiac extension.

Case Report: The case involves a 45-year-old woman with disseminated MESSMT that originated in the uterus and progressed through the iliac vein, inferior vena cava, right atrium, and into the right ventricle, which closely resembled intravenous leiomyomatosis (IVL) grossly and microscopically.

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Background: Reninoma is an extremely rare renal tumor characterized by excessive renin secretion causing secondary hypertension and hypokalemia. Reninoma is a benign and highly manageable lesion if it is discovered early and removed surgically.

Methods: We report six cases of reninoma and provide a literature review on this rare disease, highlighting the diagnostic evaluation and follow-up of each patient.

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Objectives: To analyze the CT characteristics and pathological classification of early lung adenocarcinoma (T1N0M0) with pure ground-glass opacity (pGGO).

Methods: Ninety-four lesions with pGGO on CT in 88 patients with T1N0M0 lung adenocarcinoma were selected from January 2010 to December 2012. All lesions were confirmed by pathology.

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Background: Rosai-Dorfman disease (RDD) is a rare, idiopathic, histiocytic proliferative disorder, the infrequent occurrence of which limits in-depth studies. Consequently, many characteristics of this disease remain unknown, restricting early diagnosis and proper treatment.

Methods: In this study, the literature was reviewed and a retrospective analysis of the medical records of 13 patients with RDD conducted to investigate the demographic data, clinical data, laboratory and imaging results, treatment, and prognosis of this disease.

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Gremlin is a member of the bone morphogenetic protein (BMP) antagonist family and its antagonistic effect is likely through direct binding to BMP proteins. As an antagonist of BMP, Gremlin plays a role in regulating organogenesis, body patterning and tissue differentiation. Recent studies have shown a deregulation of Gremlin in several types of human cancers.

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Article Synopsis
  • The HSulf-1 gene produces an enzyme that regulates the sulfation of heparan sulfate proteoglycans, and its silencing due to promoter hypermethylation is linked to gastric cancer.
  • The restoration of HSulf-1 expression in the gastric cancer cell line MKN28 led to reduced cell growth, movement, and invasion, while it had no significant effects on the AGS cell line.
  • HSulf-1 inhibits the Wnt/β-catenin signaling pathway in MKN28 cells but not in AGS cells, suggesting it may act as a negative regulator of cancer proliferation and invasion through this mechanism.
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There are no standard criteria for determining a sufficient resection margin in the treatment of osteosarcoma. The purposes of this study are to evaluate clinical outcomes using T1-weighted magnetic resonance imaging (MRI) for determining the margin of resection and to compare that with the results of different imaging modalities. Seventeen patients diagnosed with osteosarcoma who underwent en bloc resection with a margin of 2-3 cm based on T1-weighted MRI following chemotherapy were studied.

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Objective: To explore the effects of different oxygen flow rates during cardiopulmonary bypass (CPB) on myocardial ischemia-reperfusion (IR) injury in rabbits.

Methods: Thirty rabbits were randomized equally into groups A, B and C to receive controlled oxygen reperfusion at low, normal and high flow rates (25, 50, and 80 ml.kg(-1).

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Objective: To analyze the differential expression proteins of rat ischemia/reperfusion (I/R) lung tissues in vivo and normal lung tissues by comparative proteome analysis, and to study the mechanism of donor lung I/R injury.

Methods: Forty male SD rats were randomly divided into 2 equal groups: I/R group undergoing mimic orthotopic left lung auto-grafting and harvesting of the left lung five hours after the operation, and control group undergoing isolation of the left hilus of lung and then harvesting of the left lung. The differential proteins in the left ventricle of transplanted heart were separated by means of immobilized pH gradient-based two-dimensional gel electrophoresis (2-DE), identified by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), and searched through Matrix Science software system.

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Advances in the field of clinical lung transplantation must rely on observations made in animal models. In this study, we introduced a new procedure in the rat, orthotopic left lung transplantation without using the cuff technique, in which the donor pulmonary artery, pulmonary vein, and membranous parts of the bronchus were anastomosed continuously in the lumen using a mattress suture under a surgical microscope; meanwhile, a second, low-pressure perfusion through the pulmonary artery and turnover of the vascular stump were made, which also made the vessel anastomosis easy. Transplantations were completed in 68 rats (89.

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Aim: To determine the clinical, radiographic and pathologic characteristics, diagnostic and treatment modalities in patients with autoimmune pancreatitis (AIP).

Methods: In this retrospective study, the data of patients with diagnosed chronic pancreatitis (CP) between 1995 and 2006 in Chinese PLA General Hospital were included to screen for the cases with AIP, according to the following diagnostic criteria: (1) diagnostic histopathologic features, and abound IgG4-positive plasma cells on pancreatic tissues; (2) characteristic imaging on computed tomography and pancreatography, together with increased serum IgG, gamma-globulin levels or presence of autoantibodies; (3) response to steroid therapy. The clinical, radiographic and pathologic characteristics, diagnostic and treatment modalities, and outcome of AIP cases were reviewed.

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Objective: To investigate the role of connective tissue growth factor (CTGF) in pulmonary allograft fibrosis in rats.

Methods: The lungs of 20 Wistar rats were transplanted into 20 Sprague-Dawley(SD) rats. Ten allograft lungs were harvested 1 week postoperatively (acute rejection group,AR); the other 10 allografts were harvested 6 weeks postoperatively (chronic rejection group,CR); and ten normal Wistar rats served as a control group(normal lung, NL).

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Objective: To investigate the clinicopathological features and prognosis of bronchial mucoepidermoid carcinoma.

Methods: Twenty-one with mucoepidermoid carcinoma, 16 males and 5 females, aged 40.8 (15 ~ 72) underwent surgical treatment, 13 cases undergoing lobectomy, 3 sleeve lobectomy, 4 pneumonectomy, and 1 case thoracic exploration, from February 1988 to June 2005.

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Article Synopsis
  • The study aimed to evaluate the impact of intermittent ventilation on lung cytokines during cardiopulmonary bypass (CPB) in patients with rheumatic heart disease.
  • Thirty-six patients were split into two groups: one received intermittent ventilation every 5 minutes during CPB, while the other had no ventilation. Results showed lower levels of inflammatory markers and improved lung function in the treatment group compared to the control group.
  • The findings suggest that intermittent ventilation mitigates lung injury during CPB by reducing inflammation and protecting endothelial cells.
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Objective: To determine the protective effects and mechanism of ulinastatin on the lung injury during cardiopulmonary bypass (CPB).

Methods: Thirty patients with rheumatic heart disease (RHD) were divided into 2 groups randomly. The ulinastatin group (Group U, n = 15) received 1 x 10(4)U/kg ulinastatin intravenously before the CPB and the same amount of ulinastatin was added into the primary solution.

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Article Synopsis
  • - The study focuses on hilar cholangiocarcinoma, highlighting its low resectability and poor survival rates while examining the roles of MMP-2 and TIMP-2 in tumor invasion and prognosis.
  • - Researchers analyzed tissue samples from 50 patients, using immunohistochemical methods and image analysis software to assess MMP-2 and TIMP-2 expression levels and their ratios.
  • - Findings indicate that MMP-2 is linked to increased tumor invasion, whereas TIMP-2 inhibits it; the MMP-2 to TIMP-2 ratio could serve as a prognostic marker for patient outcomes.
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