Publications by authors named "Dian-Ke Chen"
Article Synopsis
- - A new long noncoding RNA (lncRNA) called u50535 has been identified as being significantly overexpressed in colorectal cancer (CRC) tissues and linked to worse outcomes for patients.
- - Research indicates that u50535 acts as an oncogene, enhancing tumor growth and metastasis both in laboratory studies and in living organisms.
- - The mechanism of u50535 involves activating CCL20 signaling, which boosts cell proliferation and migration, suggesting its potential as a biomarker for CRC progression.
Phosphorylated p38 (p-p38) played a pivotal role in the regulation of disease progression and correlated with tumor prognosis. Here, we characterized the prognostic effect of p-p38 in colorectal cancer (CRC). Three hundred and sixteen CRC patients in stages I-III were recruited in this study.
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- Snail and Twist are proteins that repress E-cadherin and promote a process called epithelial-mesenchymal transition, which is important for tumor spread and invasion in colorectal cancer.
- In a study of 193 colorectal cancer cases, Snail was found to be more active in patients with lymph node involvement, while Twist was more active in those with other types of metastases.
- The study indicates that higher levels of Snail are linked to lymph node metastasis, and higher levels of Twist are linked to other metastases, suggesting these two proteins play distinct roles in cancer spread through different signaling pathways.
Article Synopsis
- The study aimed to compare the safety and effectiveness of self-expanding metallic stents (SEMS) as a pre-surgical bridge versus emergency surgery for patients with left-sided malignant colorectal obstruction.
- A thorough literature search identified 14 studies with 1,083 patients, and a meta-analysis was conducted to analyze the outcomes of both methods.
- Results showed that SEMS led to lower short-term mortality and overall complications, higher resection rates, shorter operation times, and quicker recovery, indicating it is a safer and more effective option than emergency surgery.
Article Synopsis
- Researchers aimed to understand the molecular mechanisms behind adenoma, a key precursor to colorectal cancer (CRC), to aid in early detection and treatment.
- They used a sensitive technique called 2-D DIGE coupled with mass spectrometry to identify 24 proteins that were either downregulated or upregulated in adenoma tissues compared to normal colonic mucosa and CRC tissues.
- One protein, β-tropomyosin (TM-β), was significantly downregulated in both adenoma and CRC tissues, suggesting it could serve as a potential biomarker for early detection of CRC.