Construction of Functionalized α-Imino Ketones via Pd-Catalyzed C-H Addition to Nitriles/Aerobic Oxidation Sequences.

Pd(II)-catalyzed addition of sp C-H to nitrile/aerobic oxidation sequences for the preparation of functionalized α-imino ketones is described in which readily available heteroarenes and -acyl cyanohydrins were employed. Various functionalized targeted molecules can be prepared in good yields with high atom and step economy. Moreover, a broad substrate scope and the ready manipulation and availability of the reaction partners enable this protocol to be appealing to explore the chemical space of the construction of functionalized α-imino ketones with high efficiency.

[Survey of infection situation of intestinal parasites of rural residents in plain area of Shandong Province].

Objective: To understand the current situation of infections of intestinal parasites of rural residents in four cities namely Dongying, Weifang, Jining and Heze of Shandong Province.

Methods: Twenty-four villages were randomly selected as study areas. The Kato-Katz technique was applied to test the stool samples of adult residents and the cellophane tape anus method was applied to test the infection of Enterobius vermicularis of children aged 12 years or below.

[Survey of intestinal parasitic infections and related knowledge and behavior of residents in Jiaodong area of Shandong Province].

Objective: To understand the status of intestinal parasitic infections and the related knowledge and behavior in residents of Jiaodong area of Shandong Province, so as to provide the evidence for making an appropriate preventive and control strategy.

Methods: A total of 18 villages from 6 counties in Jiaodong area were selected as investigation sites according to the stratified sampling method. The feces samples of the permanent residents aged above 3 years were collected and examined by Kato-Katz technique to find the intestinal parasite eggs, and the children under 12 years old were examined by the method of cellophane anal swab to detect the Enterobius vennrmicularis eggs.

[Analysis of results of technique competition for diagnosis of parasitic diseases in Shandong Province].

Objective: To understand the capacity of Plasmodium detection and helminth detection and the mastery degree of basic knowledge of parasitic diseases.

Methods: Three professionals from each city were selected as contestants. The content of the competition contained three parts.

[Control strategy and practice of soil-transmitted parasitic diseases in Shandong Province].

Objective: To explore the sustainable development control strategies on soil-transmitted parasitic diseases appropriate to current epidemic characteristics so as to effectively reduce the epidemic level and harm to people in Shandong Province.

Methods: This project was led by the Shandong Medical Department, governed and instructed by the Shandong Institute of Parasitic Diseases, concretely implemented by the centers for disease control and prevention in counties or cities. All the work was carried out according to the Control Programming of National Key Parasitic Diseases, and with the combination of routine and key control strategies according to the actual situation.

Controllable fabrication of patterned ZnO nanorod arrays: investigations into the impacts on their morphology.

Fabricating ZnO nanorod arrays with precisely controlled morphology, alignment, and density is highly desirable but rather challenging. On the other hand, understanding the parameters that affect their final morphology and the growth mechanisms is significant to integrate such patterned ZnO nanorod arrays in various applications. Therefore, ZnO nanorod arrays with different density and morphology were fabricated by electron beam lithography (EBL) combined with the hydrothermal methods in this work.

[Cloning and identification of ROP2 gene of Toxoplasma gondii].

Objective: To amplify ROP2 from the genomic DNA of Toxoplasma gondii RH strain and construct eukaryotic expression plasmid pc-DNA3-ROP2.

Methods: Tachyzoites of T. gondii RH strain were collected and depurated to obtain genome.

Biological role of surface Toxoplasma gondii antigen in development of vaccine.

Aim: To analyze the biological role of the surface antigen of Toxoplasma gondii (T gondii) in development of vaccine.

Methods: The surface antigen of T gondii (SAG1) was expressed in vitro. The immune response of the host to the antigen was investigated by detection of specific antibody reaction to SAG1 and production of cytokines.