Publications by authors named "Dian Sulistyoningrum"

Background: Cancer cachexia in breast cancer (BC) patients is not commonly reported, particularly in Indonesia. This study assessed the prevalence of cachexia in local patients with BC receiving chemotherapy, and the associated factors.

Methods: This cross-sectional study included 160 BC patients who started chemotherapy between July 2018 and June 2022.

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Article Synopsis
  • Chemotherapy-induced peripheral neuropathy (CIPN) negatively impacts the quality of life for breast cancer patients, leading to a study that aimed to develop a prediction model using the classification and regression tree (CART) algorithm.
  • The research involved 170 breast cancer patients and used a patient-reported assessment to identify CIPN occurrences, ultimately finding that high C-reactive protein (CRP) levels, BMI, and marital status are key predictors of CIPN.
  • The CART model achieved an accuracy of 65.9% and highlighted the importance of CRP levels and neutrophil-to-lymphocyte ratios in predicting CIPN, suggesting this model could be useful for developing individualized patient care strategies in the future.
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Pregnant women are advised to take folic acid (FA) supplements before conception and during the first trimester of pregnancy. Many women continue FA supplementation throughout pregnancy, and concerns have been raised about associations between excessive FA intake and adverse maternal and child health outcomes. Unmetabolized folic acid (UMFA) is found in serum after high FA intakes and is proposed as a biomarker for excessive FA intake.

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(1) Background: Despite the postulated importance of choline during pregnancy, little is known about the choline intake of Australians during pregnancy. In this study, we estimated dietary intakes of choline in early and late pregnancy, compared those intakes to recommendations, and investigated food sources of choline in a group of pregnant women in Australia. (2) Methods: 103 pregnant women enrolled in a randomized controlled trial.

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Objectives: To observe pre- and post-treatment vitamin D level and its association with treatment and concomitant factors in breast cancer patients treated with chemotherapy.

Methods: We performed a pre-post observational analysis that nested in an ongoing prospective cohort study of breast cancer patients at Dr. Sardjito General Hospital, Yogyakarta, Indonesia.

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Objective: To describe the prevalence and determinants of vitamin D deficiency (VDD) among healthy children aged between 0 and 18 years living in South-East Asia (SEA).

Design: We systematically searched Ovid MEDLINE and Ovid EMBASE for observational studies assessing VDD among healthy children in the SEA region as the primary or secondary outcome from database inception to 6 April 2021. PubMed was used for e-pubs and publications not indexed in Medline.

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Article Synopsis
  • Poor diets high in fat, sugar, and sodium are linked to cardiovascular disease risk, particularly in obese adolescents whose eating habits may carry into adulthood.
  • A study in Yogyakarta, Indonesia, examined 179 obese adolescents, revealing that 98% had inadequate fiber intake and many exceeded fat and sugar limits.
  • The findings indicate a correlation between fiber intake and HDL cholesterol levels, suggesting that dietary improvements could reduce cardiometabolic risks in this population.
  • Future research should explore broader dietary patterns to better understand their impact on the development of cardiovascular disease in youth.
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Background: It has been shown that vitamin D is associated with obesity and the development of atherosclerosis. Less is known about this association among adolescents with obesity.

Objectives: To determine the association of vitamin D level and metabolic risk factors with carotid intima-media thickness (CIMT) among obese adolescents.

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Background: Weekly iron-folic acid (IFA) supplements are recommended for all menstruating women in countries where anemia prevalence is ≥20%; however, it is unknown whether the inclusion of folic acid in weekly IFA supplements reduces anemia.

Objectives: We examined whether the inclusion of folic acid in weekly IFA supplements conferred any benefit on hemoglobin (Hb) concentration, anemia reduction, or iron status [ferritin and soluble transferrin receptor (sTfR)], over iron alone.

Methods: In this secondary analysis of a randomized controlled trial in Malaysia, n = 311 nonpregnant women (18-45 y old) received 60 mg Fe with either 0, 0.

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  • Recent increases in childhood allergic diseases might be linked to higher folic acid intake during pregnancy, with unmetabolized folic acid (UMFA) serving as a potential indicator of excess intake.
  • A study involving 561 mother-infant pairs aimed to investigate whether UMFA and total folate levels during late pregnancy were related to allergic diseases in infants at one year old, particularly those with a family history of allergies.
  • Findings showed no significant associations between maternal UMFA or serum folate levels and allergic outcomes in infants, despite a considerable prevalence of allergies in the studied cohort.
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Introduction: Weekly iron-folic acid (IFA) supplements are recommended for all menstruating women in countries where anaemia prevalence is >20%. Anaemia caused by folate deficiency is low worldwide, and the need to include folic acid is in question. Including folic acid might reduce the risk of a neural tube defect (NTD) should a woman become pregnant.

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Introduction: Taking folic acid containing supplements prior to and during early pregnancy reduces the risk of neural tube defects. Neural tube defects occur prior to 28 days postconception, after which, there is no proven benefit of continuing to take folic acid. However, many women continue to take folic acid containing supplements throughout the pregnancy.

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The present study aimed to investigate an interaction between energy intake, physical activity and UCP2 gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years while UCP2 -866G/A gene variation was determined at baseline.

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Introduction: Folic acid (0.4 mg) taken prior to and during early pregnancy reduces the risk of neural tube defects (NTDs). Because these birth defects occur early in pregnancy, before women may know they are pregnant, many countries have mandated the addition of folic acid to food staples.

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: The prevalence of childhood obesity has increased in low- and middle-income countries, including Indonesia. It is important to identify risk factors for cardiovascular disease in obese adolescents in this region.: To assess the risk of metabolic syndrome and early vascular markers for atherosclerosis in obese Indonesian adolescents: A cross-sectional study was undertaken in obese high school students aged 15-<18 years in Yogyakarta, Indonesia.

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Background: Indonesia is facing serious air pollution. However, very few studies have been conducted to examine the health risks of air pollution in Indonesia, particularly for adolescents.

Objective: To assess the association between long-term exposure to ambient particles with a diameter of <2.

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Background: Coffee is suggested as an alternative option for weight loss but the relationship between coffee consumption and adiposity in population-based studies is still controversial. Therefore, this study was aimed at evaluating the relationship between coffee intake and adiposity in adults and to test whether uncoupling protein 2 (UCP2) gene variation was able to affect this relationship.

Methods: This was a cross-sectional study conducted in male and female adults living in the urban area of Yogyakarta, Indonesia.

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It was previously reported that dietary intake is an important trigger for systemic inflammation and one of the lifestyle factors for the development of cardiovascular diseases. The aim of this study was to evaluate the association between Dietary Inflammatory Index (DII) score and body weight, blood pressure, lipid profile and leptin in an Indonesian population. This was a cross-sectional study conducted in 503 Indonesian adults.

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Objective: To investigate the associations of estimated resting metabolic rate (RMR), body fat (BF), subcutaneous fat (SCF), visceral fat (VF), fat-free mass (FFM) percentage, BMI, and waist circumference (WC) with diabetic retinopathy (DR) in Indonesian adults with type 2 diabetes.

Research Design And Methods: This was a community-based cross-sectional study of 1,184 subjects with type 2 diabetes. DR was assessed from fundus photography and categorized as mild, moderate nonproliferative DR (NPDR), and vision-threatening DR (VTDR).

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Background: Obesity has been associated with leptin resistance and this might be caused by genetic factors. The aim of this study was to investigate the gene-lifestyle interaction between -866G/A UCP2 (uncoupling protein 2) gene polymorphism, dietary intake and leptin in a population based study.

Methods: This is a cross sectional study conducted in adults living at urban area of Yogyakarta, Indonesia.

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Background: Overfatness (overweight and obesity) is associated with an increased risk of cardiovascular disease, including elevated blood pressure, dyslipidaemia, and insulin resistance. Chronic inflammation may play a role in mediating these associations.

Objective: To investigate the association between plasma tumour necrosis factor-α and risk factors for cardiovascular disease among overweight and obese adolescents.

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Background And Objectives: Pro-inflammatory cytokines interleukin 17A (IL-17), leptin, and adiponectin have been associated with obesity and insulin resistance. Moreover, differences in sex and ethnicity as well as plasma concentration of adipocytokines and cytokines have been associated with the risk of insulin resistance. This study was conducted to elucidate whether sex differences exist in the risk of insulin resistance in Indonesian adolescents and to determine how plasma leptin, adiponectin, and IL-17 predict insulin resistance.

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Background And Objectives: Vitamin D deficiency significantly affects cardiovascular disease risk. Cardiovascular disease is epidemic in nature. Because the prevalence of cardiovascular disease has been increasing in children, it has been changing from an adulthood disease to a childhood disease.

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The ability of obese people to reduce weight in the same treatment varied. Genetic make up as well as the behavioral changes are important for the successfulness of the program. One of the most proposed genetic variations that have been reported in many intervention studies was genes that control lipolysis process.

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Article Synopsis
  • Prenatal alcohol exposure (PAE) disrupts the fetal hypothalamic-pituitary-adrenal (HPA) axis, leading to stress-related issues in adulthood, but the exact molecular mechanisms behind this disruption are still unclear.
  • * PAE affects one-carbon metabolism, which influences epigenetic processes, and results in significant differences in gene expression related to stress response in the offspring based on their mother's diet during pregnancy.
  • * The study found that while male and female offspring from alcohol-exposed mothers showed both similarities and differences in certain mRNA levels, overall these findings highlight the long-term impact of PAE on brain function and stress regulation.
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