Publications by authors named "Dian Meng"

Article Synopsis
  • Nicotiana benthamiana is a key model organism in plant biology, and researchers have generated a complete genome assembly for the plant, which is 2.85 Gb in size.
  • The study reveals that while Ty3/Gypsy retrotransposons are common in centromeres of the Solanaceae family, N. benthamiana surprisingly has many centromeres rich in satellite DNA, which are essential for their function.
  • The findings suggest that new centromeres in N. benthamiana may form through processes involving neocentromere formation, satellite expansion, and the integration of mitochondrial DNA.
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Article Synopsis
  • - Sepsis is a serious condition that results from an extreme immune response to infections, causing organ damage and high death rates, particularly in intensive care settings.
  • - The researchers developed a new deep learning model called scCaT, which combines a capsulating architecture with a Transformer to improve sepsis diagnosis using gene expression data, providing better interpretability than traditional methods.
  • - The model demonstrated strong accuracy, achieving an AUROC of 0.93 for single-cell data and 0.98 for bulk RNA cohorts, and it can identify different cell types and distinguish between sepsis and control samples based on biological pathways.
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Fusarium oxysporum is an asexual filamentous fungus that causes vascular wilt in hundreds of crop plants and poses a threat to public health through Fusariosis. F. oxysporum f.

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Chili pepper (Capsicum) is known for its unique fruit pungency due to the presence of capsaicinoids. The evolutionary history of capsaicinoid biosynthesis and the mechanism of their tissue specificity remain obscure due to the lack of high-quality Capsicum genomes. Here, we report two telomere-to-telomere (T2T) gap-free genomes of C.

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Ovarian cancer, a major gynecological malignancy, often remains undetected until advanced stages, necessitating more effective early screening methods. Existing biomarker based on differential genes often suffers from variations in clinical practice. To overcome the limitations of absolute gene expression values including batch effects and biological heterogeneity, we introduced a pairwise biosignature leveraging intra-sample differentially ranked genes (DRGs) and machine learning for ovarian cancer detection across diverse cohorts.

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Chinese motherwort (Leonurus japonicus), a member of Lamiaceae family, is a commonly used medicinal herb for treating obstetrical and gynecological diseases, producing over 280 officinal natural products. Due to limited genomic resources, little progress has been made in deciphering the biosynthetic pathway of valuable natural products in L. japonicus.

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As a class of peptide hormone, plant natriuretic peptides (PNPs) play an important role in maintaining water and salt balance in plants, as well as in the physiological processes of biotic stress and pathogen resistance. However, in plants, except for some PNPs, such as the Arabidopsis thaliana PNP-A (AtPNP-A), of which the function has not yet been thoroughly revealed, few PNPs in other plants have been reported. In this study, a PNP-A (ScPNP-A) has been identified and characterized in Stellera chamaejasme for the first time.

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The NAC proteins form one of the largest families of plant-specific transcription factors (TFs) and play essential roles in developmental processes and stress responses. In this study, we characterized a NAC domain transcription factor, , from a legume . OoNAC72 was proved to be localized in the nuclei in tobacco lower epidermal cells and had transcriptional activation activity in yeast, confirming its transcription activity.

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