BFAST: joint dimension reduction and spatial clustering with Bayesian factor analysis for zero-inflated spatial transcriptomics data.

The development of spatially resolved transcriptomics (ST) technologies has made it possible to measure gene expression profiles coupled with cellular spatial context and assist biologists in comprehensively characterizing cellular phenotype heterogeneity and tissue microenvironment. Spatial clustering is vital for biological downstream analysis. However, due to high noise and dropout events, clustering spatial transcriptomics data poses numerous challenges due to the lack of effective algorithms.

Multi-omics portrait of ductal carcinoma in situ in young women.

Background: Young patients with breast ductal carcinoma in situ (DCIS) often face a poorer prognosis. The genomic intricacies in young-onset DCIS, however, remain underexplored.

Methods: To address this gap, we undertook a comprehensive study encompassing exome, transcriptome, and vmethylome analyses.

Germinated Brown rice enhanced n-3 PUFA metabolism in type 2 diabetes patients: A randomized controlled trial.

Background: Brown rice (BR) has been considered as a potential strategy in improving T2DM. However, there are a lack of population-based trials on the association of Germinated brown rice (GBR) and diabetes.

Aims: We aimed to explore the influence of GBR diet in T2DM patients for 3 months and whether this effect relates to serum fatty acids.

3-Deoxysappanchalcone isolated from shows anticancer effects on HeLa and PC3 cell lines: invasion, migration, cell cycle arrest, and signaling pathway.

To study the antitumor activity of compound 3-desoxysulforaphane (3-DSC) isolated from , SRB assay, clone formation assay, flow cytometric cell cycle assay, scratch assay, transwell assay, and molecular docking were used to investigate the inhibitory effect of 3-DSC on HeLa and PC3 cells. The results showed that 3-DSC inhibited the cell migration and invasion by down-regulating expression of N-cadherin, Vimentin, MMP-2, and MMP-9 in HeLa and PC3 cells; It also inhibits cell proliferation by promoting the expression of CDK1 (cyclin-dependent kinases 1) and CDK2 (cyclin-dependent kinases 2), which arrests the tumor cell cycle at G2 phase. 3-DSC inhibits phosphorylation of AKT and ERK and upregulates the expression of the tumor suppressor gene p53.

Study on the chemical composition of .

Five compounds were isolated from the methanolic extract of stems and leaves including a new cassane-type butenolide norditerpenoid compound () and a new type of biphenyl compound (); the compounds were identified as Norcaesalpin-one (), 4'-hexyl 3-methyl 6-methoxy-[1,1'-biphenyl]-3,4'-dicarboxylate (), rhapontigenin (), 3-deoxysappanchalcone (), isoliquiritigenin (). Compounds - were first isolated from . Their structures were elucidaded on the basis of MS, IR, NMR spectroscopic, X-ray diffraction data analyses.

Scutellarein selectively targets multiple myeloma cells by increasing mitochondrial superoxide production and activating intrinsic apoptosis pathway.

Objectives: Scutellarein is a flavonoid monomer found in traditional Chinese medicine such as Scutellaria barbata. This study aimed to investigate the cytotoxic effect of scutellarein treatment on multiple myeloma (MM) cells.

Methods: circulating B lymphocytes (CBL) isolated from healthy donors' peripheral blood served as control for MM.