The effect of clonidine in the treatment of acute mania.

Twenty hospitalized patients have been treated for acute mania with doses of 450-750 micrograms/day of clonidine (an alpha 2-adrenergic agonist), for one month. The tolerance to the given doses was excellent. A marked decrease of the manic symptoms was noted in 65% of the patients during the first 10 days of the treatment.

Cerebral dysfunction revealed by EEG mapping in the schizoform epileptic psychosis.

Twenty schizophrenia-like psychotic patients suspected of epilepsy were explored using EEG techniques (recordings in the 10-20 International System, source derivation, EEG mapping and EEG spectral reaction mapping by photic and somesthetic stimulation). In 16 of them, latent epileptic disorders were found. EEG spiking foci could be located either: (a) in temporal, (b) fronto-basal, or (3) in the sagittal-line leads.

[Clonidine treatment in manic episodes].

The authors have treated 20 patients hospitalized for acute manic disorders with 450-750 micrograms of clonidine per day for a period of one month. The tolerance to the drug was excellent. A marked decrease in manic symptoms was noted in 65% of the patients after the first ten days of therapy.