Multicentennial cycles in continental demography synchronous with solar activity and climate stability.

Human population dynamics and their drivers are not well understood, especially over the long term and on large scales. Here, we estimate demographic growth trajectories from 9 to 3 ka BP across the entire globe by employing summed probability distributions of radiocarbon dates. Our reconstruction reveals multicentennial growth cycles on all six inhabited continents, which exhibited matching dominant frequencies and phase relations.

Incidence of cough from acute exposure to fine particulate matter (PM2.5) in Madagascar: A pilot study.

Prolonged exposure to fine particulate matter (PM2.5) is a known risk to respiratory health, causing chronic lung impairment. Yet, the immediate, acute effects of PM2.

Deficiency diseases in the Kyiv Rus' subadult population: The issue of the small sample effects.

This paper underlines the importance of the small sample effects consideration in paleopathological research providing an example of children from Kyiv Rus' cemeteries dated to the 10-13 century AD. The study presents data introduction and systematization, i.e.

Tracing long-term demographic changes: The issue of spatial scales.

This paper deals with the analysis of long-term changes in population densities at the regional and macro-regional scale and in the density of metapopulations. The following issues concerning estimations are addressed: chronological resolution of demographic changes, estimation of the weight of values for population density in order to transform the initial values included in the sample into the values that may be compared with each other at the regional scale, calibration of the transformed values into real population densities, and the estimation of the weight of values for population density at the scales of macro-regions and for the density of metapopulations. The proposed methods are tested on demographic changes in Central Europe, Southern Scandinavia, Southeastern Europe, and the Near East.

[EXPERIMENTAL AND THEORETICAL STUDIES OF HUMAN HYPERCAPNIC VENTILATORY RESPONSE WITH THE USE OF MATHEMATICAL GAS EXCHANGE MODELING].

A mathematical model of biotechnical system integrating the human cardiorespiratory system with hard- and software was designed to investigate breathing control. The model describes dynamics of carbon dioxide and oxygen in 3 biotechnical system compartments in the course of rebreathing tests. The tests do not require tanks with compressed gas and, therefore, can be performed in space flights.

Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction.

Objective: Carbohydrate metabolism disorders (CMD) significantly impact the development and progression of all forms of ischemic heart disease, and inflammation is regarded as a general pathogenetic link between CMD and ischemic heart disease.

Methods: A total of 601 patients with ST segment elevation myocardial infarction (MI) (STEMI), admitted within 24 hours from the onset of symptoms during 1 year, were included in this registry study. The blood levels of inflammation markers were measured at days 10-14 with further follow up at 1 year.

[Dynamics of duration of tracheal forced expiratory noises during long-term isolation in the "Mars-500" experiment].

Dynamics of duration of tracheal forced expiratory noises in a group of volunteers was studied before, during and after 520-days confinement. The duration did not change in most volunteers. Two volunteers demonstrated significant changes of tracheal sounds duration and some spirometric parameters.

[Survival of patients with malignant brain tumors in St. Petersburg and Arkhangelsk region].

The results of studies are presented of the dynamics on survival of patients with malignant tumors of the brain and other parts of central nervous system (C70-72) over a long period at the population level (St. Petersburg and Arkhangelsk region) by sex, age, histological structure and other parameters.

[Epidemiology of malignant tumors of the brain and other parts of the CNS in the North-West Federal District of Russia].

For the first time in Russia the dynamics of morbidity and mortality from malignant tumors of the brain and other parts of the CNS in the North-West Federal District of Russia is presented. A precise elaboration of data on cases is performed according to the database of the Population-based Cancer Registries of St. Petersburg and Arkhangelsk region.

[Efficacy of percutaneous coronary intervention in patients with ST elevation myocardial infarction and impaired glucose tolerance or diabetes mellitus].

Purpose: To assess the role of percutaneous coronary intervention (PCI) for in-hospital and one-year prognosis of ST elevation (STE) myocardial infarction (MI) patients with impaired glucose tolerance (IGT) or type 2 diabetes mellitus (T2DM).

Material And Methods: This registry study included 601 STEMI patients admitted to hospital within 24 hours after STEMI onset during one year. According to medical history, dynamics of glycemia and results of oral glucose tolerance test patients were divided into 3 groups: (1) without disturbances of carbohydrate metabolism (DCM), (2) with IGT and (3) with T2DM.

[Estimation of the forced expiration tracheal sounds intensity].

The investigation of tracheal sounds of forced expiration is realized on the basis of the mathematical model of forced expiration. It is demonstrated that a separation flow in the region of a dynamical contraction trachea during forced expiration may to cause tracheal sounds generation.

[Influence of changed gas media on acoustic parameters of human forced exhalation].

In previous study it was shown that duration of tracheal forced expiratory noises is promising to reveal negative changes of lung function after dive. The objective is a study of parameters of tracheal forced expiratory noises in changed gas media. The first experiment involved 25 volunteers (22-60 years), performed forced exhalation under normal pressure with air, oxygen-helium and oxygen-krypton mixtures.

[Characteristics of negative pressure inspiration effect on the cardiorespiratory system of humans in the conditions of 5-day dry immersion].

Changes in external respiration and central hemodynamics induced by negative (relative to atmospheric) inspiration pressure were studied in supine subjects before and on day-4 of a dry immersion (DI) experiment. Changes in the cardiorespiratory system as a result of negative inspiration pressure included rise of the amplitude of breathing motions and reduction of their frequency, and distinct breathing-related HR fluctuations. Combination of immersion and altered pressure in the mask caused breathing-related variations of systolic pressure and plethysmogram signal, and improved arterial blood oxygenation.

[Acoustic and spirometric indices of forced expiration noise in the conditions of 5-day dry immersion].

Dynamic studies of forced expiration (FE) indices involved 7 normal males aged 21 to 25 participating in a 5-d experiment with dry immersion (DI). FE spirometry was conducted simultaneously with registration of tracheal noise with the help of a microphone. Indices included acoustic duration of tracheal noise (Ta), forced lung capacity (FLC), FE volume per a second (FEV1), peak expiratory rate (PER) and time to reach (T(PER)) before DI, on DI days 1 and 4, and next day after completion.

[Biomechanics and regulation of the external respiration in the conditions of 5-day dry immersion].

The work was concerned with evaluation of the external respiration function and regulation in healthy human subjects participating in simulation of the microgravity effects by dry immersion (DI). In the baseline data collection period, in DI (days 2 and 4) and after DI completion pulmonary volumes were registered, the ratio of thoracic and abdominal components of quiet breathing and respiratory maneuvers calculated, and parameters of respiration regulation, i.e.

[Oxygen consumption by resting humans at different Elbrus altitudes].

The purpose of the work was to test experimentally the "hypoxic paradox" of growing or constant oxygen consumption by normal humans exposed to O2-deficient environments. The objective was to perform thorough statistical analysis of O2 consumption at two altitudes above sea level under the conditions of close to basic metabolism, and to develop an analytical expression for adequate description of O2 consumption dependence on altitude above seal level. The investigation was fulfilled in August, 2009 at the altitudes of 2224 and 4200 m on Elbrus flanks with participation of 4 volunteers.

[Regeneration mechanisms of ontogenetic radioadaptation in plants].

Experimental data were obtained that in pea seedlings modified by decapitation of main root had increased radioresistance (radioadaptation), fixed by various parameters of growth activity of lateral roots, and decreased ability to repair sublethal damages, detected by method of acute gamma-irradiation dose fractionation. These facts both with enlargement of dose dependence shoulder in lateral roots of decapitated seedlings led to conclusion that main role in such mechanism of radioadaptation effect of decapitation belongs to supercellular processes such as repopulation and regeneration. Conclusion was confirmed by the additional comparative investigations of cyto- and histological parameters of apical meristems of intact (control) and decapitated (experiment) lateral roots.

[Investigation of the physiological effect of heated heliox on the human external respiration parameters].

The investigation was aimed at studying and comparison of the physiological effects of heated heliox and air on the human breathing function. Tests involved eight human subjects aged 24 +/- 4 who breathed gas mixtures and air heated to 58 +/- 5 degrees C for 21 minutes. Effects were evaluated by spontaneous pneometry and forced expiration using equipment Master Screen VIASYS.

[Application of minimally invasive lumbar sympathectomy in the treatment of patients with obliterating diseases of the lower extremity vessels].

The method of performance and immediate results of miniinvasive lumbar sympathectomy using retroperitoneal miniaccess were adduced in the work. In 2005 yr on the base of division of vascular surgery were operated 19 patients. Application of endoscopic instruments and optic system of illumination gave the possibility to remove lumbar sympathetic nodes in conditions of narrow (3-5 cm) surgical access and operative field.

[Antibiotic resistance of shigellae and rationale for etiotropic therapy of Shigella infections].

The study was aimed at determining sensitivity of shigellae to antibacterial preparations and their clinical effectiveness for correcting recommendations on the empirical therapy of acute Shigella infections (ASI). The sensitivity of 164 S. flexneri strains and 80 S.

[Clinical value of the use of magnesium orotate in adolescents with syndrome of cardiac connective tissue dysplasia].

According to results of clinical and instrumental investigation magnesium orotate (50 mg/day during first week and 25 mg/day thereafter) was found to be effective therapy of children with syndrome of cardiac connective tissue dysplasia (mainly with mitral valve prolapse and anomalous chordae tendineae).

[Simultaneous operations during laparoscopic cholecystectomy].

Simultant laparoscopic operations were performed in 1993-2003 yrs period in 321 patients, including 287--using laparoscopic and 34--the combined (laparoscopic and open) access. Concurrent diseases were diagnosed preoperatively in 219 (68.2%) of patients and were disclosed while doing intraoperative revision--in 102 (31.