Publications by authors named "Diaa Ashmawy"
Hepatocellular carcinoma (HCC) is a prevalent form of malignancy that is characterized by high mortality rates and prognosis that remain suboptimal, largely due to treatment resistance mechanisms. Recent studies have implicated cancer stem cells (CSCs), particularly those expressing epithelial cell adhesion molecule (EpCAM), in HCC progression and resistance. In the present study, we sought to assess EpCAM expression in HCC patients and its correlation with various clinicopathological parameters.
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- LGR5 is a significant stem cell marker in colorectal cancer (CRC) that enhances Wnt/Β-catenin signaling, making it a potential therapeutic target.
- The study examined tissue samples from normal colon, adenomas, and CRC to analyze the expression levels of LGR5 and Β-catenin using immunohistochemical techniques.
- Findings revealed that LGR5 was absent in normal tissues but showed higher expression in adenomas and CRC, indicating its potential role in cancer development and suggesting further exploration for therapeutic applications.
Introduction: The identification of bladder detrusor muscle invasion in urothelial cancer is essential for prognosis and management. We studied the clinical, histological, and immunohistochemical expression of p16, p53, and Ki-67 in urothelial detrusor muscle-invasive bladder cancer (MIBC) and urothelial non-detrusor muscle-invasive bladder cancer (NMIBC) in Egyptian patients.
Methods: Sixty-two bladder urothelial cancer cases obtained through TURBT were included and divided into two groups: (MIBC, stage T2) and NMIBC (T1).