In vitro effects of reproterol upon tracheo- bronchial, cardiac and cerebral adenylcyclase.

In vitro researches documented that reproterol, as well as salbutamol, is a powerful stimulant of adenyl cyclase activity in the trachea and bronchi but less potent than isoprenaline. The stimulation was antagonized by beta-blockers.

Intracarotidal injection of beta-adrenergic blocking agents: variations in the carotid sinus baro- and chemoreceptor activity.

The intracarotidal injection of some bet-adrenergic blocking agents (dl-acebutolol, dl-, l-, d-alprenolol, dl-bunitrolol, dl-buthoxamine, dl-, l-, d-INPEA, dl-Ko 592, dl-metoprolol, dl-oxprenolol, dl-propranolol, dl-tolamolol) in anesthetized and bivagotomized dogs reduced the arterial blood pressure and the baro- and chemoreceptor activity. These effects seem to be mediated by an interaction with central nervous, cardiovascular and respiratory structures dependent on the carotid arteries and by a direct interference of these drugs with the carotid sinus baro- and chemoreceptor structures. Moreover, these effects were not a result of the beta-adrenolytic properties of the drugs.

Narcosis, blood glucose, plasma insulin and renin concentrations: experimental research with Althesin, thiopental and ketamine.

In the rat, narcotic doses of Althesin injected intraperitoneally did not modify blood glucose concentration nor plasma insulin concentration. On the contrary, a reduction of blood glucose concentration, associated with an increase of plasma insulin concentration was observed when narcotic doses of thiopental and ketamine were administered. Plasma renin concentrations decreased after injection of Althesin and thiopental but increased after injection of ketamine.