Publications by authors named "DiGiovanni G"
Article Synopsis
- Precontoured cancellous allograft wedges are increasingly used in foot and ankle surgeries due to their ease of use and potential to shorten surgery time, but concerns about high resorption rates have been raised.
- A study reviewed 334 patients from 2017 to 2022, finding that 7.2% experienced graft resorption and 2.9% had nonunion, often influenced by factors like older age and BMI over 30.
- The overall complication rate was 10%, highlighting the need for clinicians to inform patients about these risks when considering these grafts for surgery.
Article Synopsis
- PCFD patients show more internal rotation of the talus in the ankle mortise, but this study is the first to examine how talar axial rotation changes after surgery for PCFD.
- The study included 27 adults who had PCFD reconstruction, measuring talar axial rotation before and after surgery using weightbearing CT scans along with various radiographic parameters.
- Results indicate that surgery leads to a significant external rotation of the talus, but this change in rotation did not correlate with other radiographic measurements or patient-reported outcomes, except for an increased postoperative pain intensity.
Background: Both an open cheilectomy with a Moberg osteotomy and percutaneous cheilectomy have been successfully used to treat hallux rigidus and preserve motion.However, there have been no studies that have compared these 2 procedures using validated patient-reported outcomes such as the Patient Reported Outcome Measurement Information System.
Methods: A retrospective review of hallux rigidus patients between January 2016 and July 2021 collected 48 percutaneous cheilectomy (PC) patients and 71 open cheilectomy with Moberg (OCM) patients.
Background: The current literature shows similar clinical outcomes between first metatarsophalangeal (MTP) joint arthrodesis and synthetic cartilage implant (SCI) hemiarthroplasty in the treatment of hallux rigidus; however, prior studies have not reported validated patient-reported outcome measures (PROMs). To our knowledge, this is the first study to compare PROMs using 6 domains of the validated Patient-Reported Outcomes Measurement Information System (PROMIS) in patients treated for hallux rigidus with MTP joint arthrodesis and with SCI hemiarthroplasty. In addition, this novel study provides comparative data on the complication and revision rates for each procedure.
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- Hallux valgus deformity, common in individuals aged 65 and older, can complicate surgical correction due to factors like poor bone quality and recovery challenges, prompting a comparison of outcomes between two surgical techniques: open Lapidus and minimally invasive chevron Akin osteotomy.
- A study reviewed 62 patients aged 65 and older and assessed their radiographic and clinical outcomes using PROMIS scores preoperatively and at 1 and 2 years post-surgery, finding no significant differences between the two surgical approaches.
- Both surgical groups showed improvement in pain and function over time, with notable advancements in the PROMIS score for physical function in the minimally invasive group after 1 year, but no clinical or statistical differences were ultimately
Article Synopsis
- Hallux valgus is a foot problem where the big toe angles toward the other toes, and a surgery called modified Lapidus is often done to fix it.
- This study looked at how the position of the big toe after surgery affects how patients feel about their pain and ability to move.
- Results showed that after surgery, patients felt better in areas like physical activity and pain, but the position change of the toe didn't affect their mental health scores.
Article Synopsis
- The study explores prognostic awareness in older adults with cancer, highlighting its importance in aligning care with patient goals and identifying those who may need support to improve their understanding of their prognosis.
- Conducted at a geriatric oncology clinic, the research analyzed responses from 257 elderly patients who estimated their life expectancy, revealing that 62% had poor prognostic awareness, with many underestimating their longevity.
- Factors linked to poor prognostic awareness included demographic characteristics and aging-related issues, and the study found that only 49% of patients were open to discussing their prognosis, indicating a need for improved communication and intervention.
Background: Minimally invasive bunionectomy (MISB) has emerged as a popular approach to treat symptomatic hallux valgus deformity. Although previous studies focused on distal foot width changes postsurgery, this research introduces a novel midshaft measurement to evaluate proximal transverse midfoot width, aiming for a comprehensive understanding of foot changes post-MISB.
Methods: A retrospective review of 44 HV patients from an institutional registry was conducted.
Background: Joint replacement procedures have traditionally been performed in an inpatient setting to minimize complication rates. There is growing evidence that total ankle arthroplasty (TAA) can safely be performed as an outpatient procedure, with the potential benefits of decreased health care expenses and improved patient satisfaction. Prior studies have not reliably made a distinction between outpatient TAA defined as length of stay <1 day and same-day discharge.
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- * Researchers found that YAP/TAZ activity is normally activated in type 2 alveolar cells (AT2) after lung injury, and removing this activity causes significant issues like abnormal cell remodeling and increased inflammation.
- * The results suggest that maintaining YAP/TAZ activity in AT2 cells is crucial for proper lung healing and preventing fibrosis, highlighting their importance in effective alveolar regeneration.
Introduction: Aging-related concerns can increase the risk of treatment toxicities among older adults considering adjuvant chemotherapy. We previously demonstrated that older adults with cancer who reported feeling older than their chronological age (i.e.
View Article and Find Full Text PDFObjectives: Explore how older patients utilize their social networks to inform prognostic understanding.
Methods: In a pilot study of adults (≥65 years old) with advanced cancer, 16 patients completed surveys, social network maps, and semi-structured interviews exploring with whom they preferred to communicate about their illness. Interviews were analyzed using open-coding, and codes were categorized into emergent themes.
Background: Little is known about how older adults (OA) with advanced cancer interact with social network members (NM), and the nature of communication. This qualitative study aimed to characterize the processes by which OAs with cancer engage with NMs regarding their illness.
Methods: OAs 65 + with advanced cancer and considering treatment (n = 29) and NMs (n = 18) underwent semi-structured interviews asking 1) about their illness understanding; 2) to identify NMs with whom OAs discuss health-related matters; and 3) to describe the content, process, and impact of those illness-related conversations.
Context: Systematic collection of patient-reported outcomes (PROs) reduces symptom burden and improves quality of life. The ability of older adults to complete PROs, however, has not been thoroughly studied.
Objectives: To determine whether older adults with advanced cancer received assistance completing PROs, the nature of the assistance, the factors associated with receiving assistance, and how the prevalence of assistance changed over time.
Introduction: Treatment toxicities are common in older adults with cancer and consequently, treatment modifications are sometimes considered. We evaluated the prevalence and factors associated with treatment modifications at the first cycle in older patients receiving palliative systemic treatment.
Methods: Patients (n = 369) from the GAP 70+ Trial (NCT02054741; PI: Mohile) usual care arm were included.
Background: Maintaining functional status is important to older adults with cancer, but data are limited on how systemic treatments affect functional status. We systematically reviewed changes in functional status during systemic cancer treatments and identified characteristics associated with functional decline and improvement.
Methods: We searched PubMed, Embase, Web of Science, and Cochrane Register of Controlled Trials for articles examining characteristics associated with functional changes in older adults during systemic cancer treatment published in English between database inception and January 11, 2019 (PROSPERO CRD42019123125).
Introduction: Osteoporosis-related hip fractures are associated with high mortality and costs. The optimum type of treatment for such fractures is controversial. To shed some light on this issue, the surgical treatment and management of osteoporotic hip fractures were discussed during a hip fracture surgical working group at the 2009 International Society For Fracture Repair Annual Meeting comprising leading experts in the field.
View Article and Find Full Text PDFTo assess the drug-behavior interaction effects with an 8-year-old boy wih attention deficit hyperactivity disorder, common classroom antecedent (e.g., seating arrangement) and consequent (e.
View Article and Find Full Text PDFGene transfer of Alcaligenes eutrophus JMP134 plasmid pJP4 to indigenous soil recipients.
Appl Environ Microbiol
July 1996
This study evaluated the potential for gene transfer of a large catabolic plasmid from an introduced organism to indigenous soil recipients. The donor organism Alcaligenes eutrophus JMP134 contained the 80-kb plasmid pJP4, which contains genes that code for mercury resistance. Genes on this plasmid plus chromosomal genes also allow degradation of 2,4-dichloruphenoxyacetic acid (2,4-D).
View Article and Find Full Text PDFUsing radioimmunoassay methods, the blood of patients with pancreatic tumors was screened for circulating polypeptide hormones. This screening discovered pancreatic polypeptide in abnormally high concentration in the serum of six of seven patients with adenocarcinomas of the bile duct. The assay appears to be very sensitive finding excessive residual pancreatic polypeptide production after palliative resections.
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