Publications by authors named "Di-Xuan Jiang"
Article Synopsis
- The study investigated the effectiveness and safety of three antiviral treatments (azvudine, nirmatrelvir/ritonavir, and molnupiravir) for adults with mild-to-moderate COVID-19 at a hospital in China.
- It included 157 patients divided into the three treatment groups, and measured the time it took for patients to achieve nucleic acid negative conversion (NANC).
- Results showed no significant differences in conversion times, hospital stays, or adverse effects among the treatments, indicating azvudine could be as effective as the others in treating mild-to-moderate COVID-19.
Gut Microbiota Protected Against Pneumonia Restoring Treg/Th17 Balance and Metabolism.
Front Cell Infect Microbiol
July 2022
Article Synopsis
- The study investigates the "entero-pulmonary axis" theory, which links pneumonia to gut microbiota disturbance and an imbalance in immune responses (Treg/Th17).
- Using acute pneumonia mouse models, the researchers performed fecal microbiota transplantation (FMT) and assessed its effects on lung and spleen health, immune cell balance, and serum inflammation markers.
- Results showed that FMT improved gut microbiota diversity, reduced inflammation and tissue damage, and restored immune balance in pneumonia-affected mice, suggesting FMT could be a potential treatment strategy for pneumonia.
Background/aims: Cigarette smoking is a major risk factor of chronic obstructive pulmonary disease. This study aimed to examine the effects of cigarette smoke extract (CSE) on alveolar type II epithelial cells (AECII) and investigate the underlying mechanism.
Methods: Primary AECII were isolated from rat lung tissues and exposed to CSE.