Publications by authors named "Di-Fei Nie"
Mitochondrial fumarate promotes ischemia/reperfusion-induced tubular injury.
Acta Physiol (Oxf)
April 2024
Article Synopsis
- Mitochondrial dysfunction plays a key role in causing injury to tubular epithelial cells during renal ischemic/reperfusion injury (I/RI), although the specific mechanisms are not fully understood.
- Using advanced metabolic profiling techniques, the study found that tubular injury, which happens during the reperfusion phase, is linked to increased glycolysis and mitochondrial dysfunction.
- The research revealed that fumarate, produced from dysfunctional mitochondria and associated with a deficiency in fumarate hydratase, disrupts glutathione balance, leading to tubular injury, while targeting the signaling pathways can provide potential therapeutic benefits.